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Tchem
PTPN1
Tyrosine-protein phosphatase non-receptor type 1

Protein Summary
Description
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular process ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371621
  • ENSP00000360683
  • ENSG00000196396

Symbol
  • PTP1B
  • PTP1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
hub protein
1
biological process
0.97
kinase
0.95
transcription factor binding site profile
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1785.2   (req: < 5)
Gene RIFs: 201   (req: <= 3)
Antibodies: 683   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1785.2   (req: >= 5)
Gene RIFs: 201   (req: > 3)
Antibodies: 683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 754
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
2
2
2
88.4
lymphocyte count
3
3
3
88.2
hematocrit
4
2
4
84.2
eosinophil count
2
2
2
83.6
eosinophil percentage of leukocytes
2
2
2
74.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
2
88.4
lymphocyte count
3
88.2
hematocrit
4
84.2
eosinophil count
2
83.6
eosinophil percentage of leukocytes
2
74.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 1
VGNC:9943
469970
Macaque
protein tyrosine phosphatase, non-receptor type 1
702016
Mouse
MGI:97805
19246
Rat
RGD:61965
24697
Dog
protein tyrosine phosphatase, non-receptor type 1
VGNC:45167
477263
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 1
Macaque
protein tyrosine phosphatase, non-receptor type 1
Mouse
Rat
Dog
protein tyrosine phosphatase, non-receptor type 1
Protein Structure (263 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P18031-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 263
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (144)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Growth hormone receptor signaling
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene expression (Transcription)
Generic Transcription Pathway
Growth hormone receptor signaling
Hemostasis
Gene Ontology Terms (42)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (255)
1 – 10 of 255
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.999970167
p_ni:  0.000029833
Data Source:  BioPlex
TMEM63A
Tdark
Family:  IC
Novelty:  0.33131011
p_int:  0.998556131
p_ni:  0.001443869
Score:  0.211
Data Source:  BioPlex,STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.993653546
p_ni:  0.006346454
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.986824389
p_ni:  0.013175611
Data Source:  BioPlex
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.985866388
p_ni:  0.014133612
Score:  0.161
Data Source:  BioPlex,STRINGDB
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.982825369
p_ni:  0.017174631
Data Source:  BioPlex
TSPAN31
Tbio
Novelty:  0.13580467
p_int:  0.960927592
p_ni:  0.039072408
p_wrong:  1e-9
Data Source:  BioPlex
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.930695679
p_ni:  0.069304321
Data Source:  BioPlex
SLCO6A1
Tbio
Family:  Transporter
Novelty:  0.07836028
p_int:  0.925048404
p_ni:  0.074951594
p_wrong:  2e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.915845716
p_ni:  0.084154256
p_wrong:  2.8e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  1785.20

PubMed score by year
PubTator Score  913.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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