Tbio TCP1 T-complex protein 1 subunit alpha

Protein Summary

Description

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P17987
• E1P5B2
• Q15556
• Q5TCM3
• TCP-1-alpha

Gene Name

• TCP1

Ensembl ID

• ENST00000321394
• ENSP00000317334
• ENSG00000120438

Symbol

• CCT1
• CCTA
• CCT1
• CCTa
• D6S230E
• CCT-alpha
• TCP-1-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	1
interacting protein	1
kinase perturbation	0.97
co-expressed gene	0.96

Protein Classes

PANTHER Classes

Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Alpha

DTO Classes

Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.91   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 607   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.91   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 607   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0