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Tbio
TCP1
T-complex protein 1 subunit alpha

Protein Summary
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321394
  • ENSP00000317334
  • ENSG00000120438

Symbol
  • CCT1
  • CCTA
  • CCT1
  • CCTa
  • D6S230E
  • CCT-alpha
  • TCP-1-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
kinase perturbation
0.97
co-expressed gene
0.96


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.99   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 607   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.99   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 607   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
t-complex 1
VGNC:8578
739754
Macaque
t-complex 1
702500
Mouse
MGI:98535
21454
Rat
RGD:3832
24818
Dog
t-complex 1
VGNC:47207
484064
Species
Name
OMA
EggNOG
Inparanoid
Chimp
t-complex 1
Macaque
t-complex 1
Mouse
Rat
Dog
t-complex 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P17987-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Chaperonin-mediated protein folding
Reactome
Cilium Assembly
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Chaperonin-mediated protein folding
Cilium Assembly
Gene Ontology Terms (30)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (450)
1 – 10 of 450
KLHDC8A
Tdark
Novelty: 1.43751731
p_int: 0.99311677
p_ni: 0.00688323
Score: 0.33
Data Source: BioPlex,STRINGDB
TUBAL3
Tdark
Novelty: 1.0330894
p_int: 0.992432128
p_ni: 0.007567872
Score: 0.918
Data Source: BioPlex,STRINGDB
DCAF11
Tbio
Novelty: 0.08318661
p_int: 0.991925903
p_ni: 0.008074097
Score: 0.367
Data Source: BioPlex,STRINGDB
CERCAM
Tdark
Family: Enzyme
Novelty: 0.33392502
p_int: 0.988384736
p_ni: 0.011615264
Data Source: BioPlex
KLHL33
Tdark
Novelty: 1.42677156
p_int: 0.987466197
p_ni: 0.012533803
Score: 0.216
Data Source: BioPlex,STRINGDB
PRDX2
Tbio
Novelty: 0.00189751
p_int: 0.981502773
p_ni: 0.018497227
Score: 0.365
Data Source: BioPlex,STRINGDB
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.978554682
p_ni: 0.021445318
Score: 0.999
Data Source: BioPlex,STRINGDB
CCT3
Tbio
Novelty: 0.01642521
p_int: 0.977411709
p_ni: 0.022588291
Score: 0.999
Data Source: BioPlex,STRINGDB
MYH7B
Tbio
Novelty: 0.00864941
p_int: 0.976768787
p_ni: 0.023231213
Data Source: BioPlex
THOC3
Tbio
Novelty: 0.04716962
p_int: 0.975784118
p_ni: 0.024215882
Score: 0.397
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  230.99

PubMed score by year
PubTator Score  97.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer