You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PSMC3
26S proteasome regulatory subunit 6A

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are com ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298852
  • ENSP00000298852
  • ENSG00000165916
  • ENST00000619920
  • ENSP00000481029

Symbol
  • TBP1
  • TBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
biological process
0.99
molecular function
0.96
kinase perturbation
0.91
transcription factor perturbation
0.91


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.11   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 461   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.11   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 461   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (451)
TRAF4
Tbio
Novelty:  0.01317133
p_int:  0.999999481
p_ni:  5.18e-7
Score:  0.36
Data Source:  BioPlex,STRINGDB
EIF2D
Tbio
Novelty:  0.03765592
p_int:  0.999999266
p_ni:  6.72e-7
p_wrong:  6.2e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
ELF2
Tbio
Family:  TF
Novelty:  0.01302604
p_int:  0.999998977
p_ni:  0.000001023
Data Source:  BioPlex
RAI14
Tbio
Novelty:  0.06291577
p_int:  0.999995204
p_ni:  0.000004796
Score:  0.349
Data Source:  BioPlex,STRINGDB
MPRIP
Tbio
Family:  Enzyme
Novelty:  0.03253403
p_int:  0.999992321
p_ni:  0.000007655
p_wrong:  2.4e-8
Data Source:  BioPlex
PSMD9
Tbio
Family:  Enzyme
Novelty:  0.02173534
p_int:  0.999935923
p_ni:  0.000064077
Score:  0.999
Data Source:  BioPlex,STRINGDB
RNASEH2C
Tbio
Family:  Enzyme
Novelty:  0.06148299
p_int:  0.999852581
p_ni:  0.00000207
p_wrong:  0.000145349
Score:  0.22
Data Source:  BioPlex,STRINGDB
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.999842053
p_ni:  0.000157947
Data Source:  BioPlex
FAM117B
Tdark
Novelty:  1.06316483
p_int:  0.999683256
p_ni:  0.000316192
p_wrong:  5.52e-7
Data Source:  BioPlex
RASSF7
Tbio
Novelty:  0.08011259
p_int:  0.999572191
p_ni:  0.000427809
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (160)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 149
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (69)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
9
14
99.3
apolipoprotein A 1 measurement
2
8
9
98.5
IGF-1 measurement
1
6
6
95.7
C-reactive protein measurement
3
5
6
94.5
intraocular pressure measurement
5
5
6
94.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
14
99.3
apolipoprotein A 1 measurement
9
98.5
IGF-1 measurement
6
95.7
C-reactive protein measurement
6
94.5
intraocular pressure measurement
6
94.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, ATPase 3
VGNC:8273
451172
Macaque
proteasome 26S subunit, ATPase 3
713356
Mouse
MGI:1098754
19182
Rat
RGD:61905
29677
Dog
proteasome 26S subunit, ATPase 3
475980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, ATPase 3
Macaque
proteasome 26S subunit, ATPase 3
Mouse
Rat
Dog
proteasome 26S subunit, ATPase 3
Publication Statistics
PubMed Score 24.11
PubMed score by year
PubTator Score 14.96
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title