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Tclin
FLT1
Vascular endothelial growth factor receptor 1

Protein Summary
Description
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282397
  • ENSP00000282397
  • ENSG00000102755
  • ENST00000539099
  • ENSP00000442630
  • ENST00000541932
  • ENSP00000437631
  • ENST00000543394
  • ENSP00000437841
  • ENST00000615840
  • ENSP00000484039

Symbol
  • FLT
  • FRT
  • VEGFR1
  • FLT
  • FLT-1
  • VEGFR1
  • VEGFR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
1
molecular function
0.99
biological process
0.94
trait
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2334.76   (req: < 5)
Gene RIFs: 708   (req: <= 3)
Antibodies: 1445   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2334.76   (req: >= 5)
Gene RIFs: 708   (req: > 3)
Antibodies: 1445   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 316
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12