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Tclin
FLT1
Vascular endothelial growth factor receptor 1

Protein Summary
Description
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282397
  • ENSP00000282397
  • ENSG00000102755
  • ENST00000539099
  • ENSP00000442630
  • ENST00000541932
  • ENSP00000437631
  • ENST00000543394
  • ENSP00000437841
  • ENST00000615840
  • ENSP00000484039

Symbol
  • FLT
  • FRT
  • VEGFR1
  • FLT
  • FLT-1
  • VEGFR1
  • VEGFR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
1
molecular function
0.99
biological process
0.94
trait
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2129.86   (req: < 5)
Gene RIFs: 582   (req: <= 3)
Antibodies: 1445   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2129.86   (req: >= 5)
Gene RIFs: 582   (req: > 3)
Antibodies: 1445   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 314
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (12)
sunitinib
Rendered image for sunitinib
nintedanib
Rendered image for nintedanib
ponatinib
Rendered image for ponatinib
sorafenib
Rendered image for sorafenib
pazopanib
Rendered image for pazopanib
axitinib
Rendered image for axitinib
regorafenib
Rendered image for regorafenib
cabozantinib
Rendered image for cabozantinib
vandetanib
Rendered image for vandetanib
lenvatinib
Rendered image for lenvatinib
Protein-Protein Interactions (251)
VEGFA
Tclin
Novelty:  0.0000378
p_int:  0.999999068
p_ni:  9.32e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.998320769
p_ni:  0.001502792
p_wrong:  0.00017644
Score:  0.173
Data Source:  BioPlex,STRINGDB
PGF
Tclin
Novelty:  0.00061576
Score:  0.999
Data Source:  Reactome,STRINGDB
VEGFB
Tclin
Novelty:  0.00293322
Score:  0.999
Data Source:  Reactome,STRINGDB
NRP1
Tchem
Novelty:  0.00153628
Score:  0.995
Data Source:  STRINGDB
NRP2
Tbio
Novelty:  0.00764179
Score:  0.988
Data Source:  Reactome,STRINGDB
KDR
Tclin
Family:  Kinase
Novelty:  0.00016219
Score:  0.988
Data Source:  STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
Score:  0.982
Data Source:  STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.976
Data Source:  STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (35)
Neurophilin interactions with VEGF and VEGFR (R-HSA-194306)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurophilin interactions with VEGF and VEGFR
Reactome
Signal Transduction
Reactome
Signaling by Receptor Tyrosine Kinases
Reactome
Signaling by VEGF
Reactome
VEGF binds to VEGFR leading to receptor dimerization
Name
Explore in Pharos
Explore in Source
Neurophilin interactions with VEGF and VEGFR
Signal Transduction
Signaling by Receptor Tyrosine Kinases
Signaling by VEGF
VEGF binds to VEGFR leading to receptor dimerization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (41)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
4
1.1
89.5
monocyte count
1
1
1
82
monocyte percentage of leukocytes
1
1
1
76.9
placenta growth factor measurement
1
1
1
74.6
refractive error measurement
2
2
1
6.1
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
89.5
monocyte count
1
82
monocyte percentage of leukocytes
1
76.9
placenta growth factor measurement
1
74.6
refractive error measurement
1
6.1
70.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fms related tyrosine kinase 1
VGNC:7287
452512
Macaque
fms related tyrosine kinase 1
574133
Mouse
MGI:95558
14254
Rat
RGD:2621
54251
Dog
fms related tyrosine kinase 1
VGNC:40907
403727
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fms related tyrosine kinase 1
Macaque
fms related tyrosine kinase 1
Mouse
Rat
Dog
fms related tyrosine kinase 1
Publication Statistics
PubMed Score 2129.86
PubMed score by year
PubTator Score 1779.42
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title