Tchem IGFBP3 Insulin-like growth factor-binding protein 3

Protein Summary

Description

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P17936
• A4D2F5
• D3DVM0
• Q2V509
• Q6P1M6
• Q9UCL4
• IBP-3

Gene Name

• IGFBP3

Ensembl ID

• ENST00000275521
• ENSP00000275521
• ENSG00000146674
• ENST00000381083
• ENSP00000370473

Symbol

• IBP3
• IBP3
• BP-53

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
PubMedID	0.98
protein domain	0.92
virus perturbation	0.92
small molecule perturbation	0.88

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Insulin-like Growth Factor-binding Protein 3

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Insulin-like Growth Factor-binding Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2660.87   (req: < 5)

Gene RIFs: 615   (req: <= 3)

Antibodies: 647   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2660.87   (req: >= 5)

Gene RIFs: 615   (req: > 3)

Antibodies: 647   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 39

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0