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Tchem
IGFBP3
Insulin-like growth factor-binding protein 3

Protein Summary
Description
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275521
  • ENSP00000275521
  • ENSG00000146674
  • ENST00000381083
  • ENSP00000370473

Symbol
  • IBP3
  • IBP3
  • BP-53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.98
protein domain
0.92
virus perturbation
0.92
small molecule perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2513.85   (req: < 5)
Gene RIFs: 532   (req: <= 3)
Antibodies: 647   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2513.85   (req: >= 5)
Gene RIFs: 532   (req: > 3)
Antibodies: 647   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 39
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
61.7
body height
1
1
1
41.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
61.7
body height
1
41.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor binding protein 3
VGNC:4398
463396
Macaque
insulin like growth factor binding protein 3
696868
Mouse
MGI:96438
16009
Rat
RGD:2874
24484
Dog
insulin like growth factor binding protein 3
VGNC:41904
100855619
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor binding protein 3
Macaque
insulin like growth factor binding protein 3
Mouse
Rat
Dog
insulin like growth factor binding protein 3
Pathways (22)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (235)
1 – 10 of 235
IGF1
Tbio
Novelty: 0.00003878
Score: 0.998
Data Source: Reactome,STRINGDB
IGF2
Tbio
Novelty: 0.00021277
Score: 0.996
Data Source: Reactome,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.985
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.984
Data Source: STRINGDB
IGFALS
Tbio
Novelty: 0.0287658
Score: 0.978
Data Source: Reactome,STRINGDB
PLG
Tclin
Family: Enzyme
Novelty: 0.00004806
Score: 0.975
Data Source: Reactome,STRINGDB
KLK3
Tchem
Family: Enzyme
Novelty: 0.00003606
Score: 0.971
Data Source: Reactome,STRINGDB
IGFBP7
Tbio
Novelty: 0.00249209
Score: 0.966
Data Source: STRINGDB
MMP2
Tchem
Family: Enzyme
Novelty: 0.00012762
Score: 0.966
Data Source: Reactome,STRINGDB
MMP1
Tchem
Family: Enzyme
Novelty: 0.00030922
Score: 0.959
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  2513.85

PubMed score by year
PubTator Score  3284.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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