Tchem LGALS3 Galectin-3

Protein Summary

Description

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P17931
• B2RC38
• Q16005
• Q6IBA7
• Q96J47
• Gal-3

Gene Name

• LGALS3

Ensembl ID

• ENST00000254301
• ENSP00000254301
• ENSG00000131981

Symbol

• MAC2
• L31
• GAL3
• MAC2
• CBP35
• GALBP
• GALIG
• LGALS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
biological process	0.93
biological term	0.86
kinase perturbation	0.84
disease	0.78

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Galectin-3

Protein / Cell Adhesion Molecule / Galectin-3

DTO Classes

Protein / Signaling / Galectin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3586.84   (req: < 5)

Gene RIFs: 609   (req: <= 3)

Antibodies: 1455   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3586.84   (req: >= 5)

Gene RIFs: 609   (req: > 3)

Antibodies: 1455   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 38

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (38)

Explore Active Ligands

1 – 10 of 38

CHEMBL4066068

LGALS3Tchem

pKd : 7.2

CHEMBL4104417

LGALS3Tchem

pKd : 7.16

CHEMBL4091143

LGALS3Tchem

pKd : 7.92

CHEMBL4065371

LGALS3Tchem

pKd : 7.57

CHEMBL4071878

LGALS3Tchem

pKd : 6.3

CHEMBL2313626

LGALS3Tchem

pKd : 7.89

CHEMBL4086521

LGALS3Tchem

pKd : 6.41

CHEMBL2313627

LGALS3Tchem

pKd : 7.31

CHEMBL1253187

LGALS3Tchem

pKd : 6.13

CHEMBL4102016

LGALS3Tchem

pKd : 6.64

Protein-Protein Interactions (310)

Explore Interacting Targets

1 – 10 of 310

• See Interactions on String-DB

SDK1

Tbio

Novelty:  0.05094526

p_int:  0.999999932

p_ni:  1.3e-8

p_wrong:  5.5e-8

Score:  0.179

Data Source:  BioPlex,STRINGDB

CSPG4

Tbio

Novelty:  0.0038499

p_int:  0.999999648

p_ni:  3.24e-7

p_wrong:  2.7e-8

Score:  0.63

Data Source:  BioPlex,STRINGDB

PTPRJ

Tbio

Family:  Enzyme

Novelty:  0.00786921

p_int:  0.999999223

p_ni:  2.31e-7

p_wrong:  5.47e-7

Score:  0.299

Data Source:  BioPlex,STRINGDB

SLC12A6

Tbio

Family:  Transporter

Novelty:  0.0132619

p_int:  0.999999147

p_ni:  8.53e-7

Score:  0.297

Data Source:  BioPlex,STRINGDB

LAMA1

Tbio

Novelty:  0.00852401

p_int:  0.999998928

p_ni:  0.000001062

p_wrong:  1e-8

Score:  0.6

Data Source:  BioPlex,STRINGDB

SDK2

Tdark

Novelty:  0.08867136

p_int:  0.999998879

p_ni:  0.00000112

Data Source:  BioPlex

KIAA1549

Tbio

Novelty:  0.01224835

p_int:  0.999998723

p_ni:  3e-9

p_wrong:  0.000001274

Score:  0.251

Data Source:  BioPlex,STRINGDB

ITGA1

Tbio

Novelty:  0.00545805

p_int:  0.999998433

p_ni:  0.00000155

p_wrong:  1.7e-8

Score:  0.351

Data Source:  BioPlex,STRINGDB

LAMA4

Tbio

Novelty:  0.01288371

p_int:  0.999998431

p_ni:  0.000001569

Score:  0.235

Data Source:  BioPlex,STRINGDB

COLEC12

Tbio

Novelty:  0.02882427

p_int:  0.999989813

p_ni:  0.000010187

Score:  0.237

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (32)

Reactome (11)

PathwayCommons (2)

WikiPathways (19)

Advanced glycosylation endproduct receptor signaling (R-HSA-879415)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Advanced glycosylation endproduct receptor signaling	13 targets	R-HSA-879415
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249

Name	Explore in Pharos	Explore in Source
Advanced glycosylation endproduct receptor signaling	13 targets	R-HSA-879415
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (50)

Functions (8)

Components (15)

Processes (27)

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1 – 8 of 8

GO Term	Evidence	Assigned by
chemoattractant activity	Inferred from Direct Assay (IDA)	BHF-UCL
IgE binding	Inferred from Direct Assay (IDA)	BHF-UCL
laminin binding	Inferred from Direct Assay (IDA)	BHF-UCL
oligosaccharide binding	Inferred from Direct Assay (IDA)	UniProtKB
protein phosphatase binding	Inferred from Physical Interaction (IPI)	ARUK-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
carbohydrate binding	Traceable Author Statement (TAS)	ProtInc
protein phosphatase inhibitor activity	Inferred by Curator (IC)	ARUK-UCL

Disease Associations ()

No disease associations found

GWAS Traits (7)

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1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
galectin-3 measurement	EFO_0008137	1	2	2		95.7
mean platelet volume	EFO_0004584	2	2	2		87.2
protein measurement	EFO_0004747	1	1	1		53.6
red blood cell distribution width	EFO_0005192	1	1	1		8.3
self reported educational attainment	EFO_0004784	1	1	1		0.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
galectin-3 measurement	EFO_0008137	2		95.7
mean platelet volume	EFO_0004584	2		87.2
protein measurement	EFO_0004747	1		53.6
red blood cell distribution width	EFO_0005192	1		8.3
self reported educational attainment	EFO_0004784	1		0.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Differentiation
Disulfide bond
IgE-binding protein
Immunity
Innate immunity
Lectin

GWAS Trait Find Similar Targets

No Header	No Header
galectin-3 measurement
intelligence
mean platelet volume
protein measurement
red blood cell distribution width
schizophrenia
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
cellular phenotype
digestive/alimentary phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	galectin 3	VGNC:48879	744038
Macaque	galectin 3		697290
Mouse	lectin, galactose binding, soluble 3	MGI:96778	16854
Rat	galectin 3	RGD:69356	83781
Dog	galectin 3	VGNC:42648	404021

Species	Name	OMA	EggNOG	Inparanoid
Chimp	galectin 3
Macaque	galectin 3
Mouse	lectin, galactose binding, soluble 3
Rat	galectin 3
Dog	galectin 3

Publication Statistics

PubMed Score 3586.84

PubMed score by year

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PubTator Score 1911.76

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Related Publications

Text Mined References (675)

GeneRif Annotations (609)

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PMID	Year	Title