Tchem LGALS3 Galectin-3

Protein Summary

Description

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P17931
• B2RC38
• Q16005
• Q6IBA7
• Q96J47
• Gal-3

Gene Name

• LGALS3

Ensembl ID

• ENST00000254301
• ENSP00000254301
• ENSG00000131981

Symbol

• MAC2
• L31
• GAL3
• MAC2
• CBP35
• GALBP
• GALIG
• LGALS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
biological process	0.93
biological term	0.86
kinase perturbation	0.84
disease	0.78

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Galectin-3

Protein / Cell Adhesion Molecule / Galectin-3

DTO Classes

Protein / Signaling / Galectin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3963.65   (req: < 5)

Gene RIFs: 863   (req: <= 3)

Antibodies: 1455   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3963.65   (req: >= 5)

Gene RIFs: 863   (req: > 3)

Antibodies: 1455   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0