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Tchem
LGALS3
Galectin-3

Protein Summary
Description
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition doma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254301
  • ENSP00000254301
  • ENSG00000131981

Symbol
  • MAC2
  • L31
  • GAL3
  • MAC2
  • CBP35
  • GALBP
  • GALIG
  • LGALS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
biological process
0.93
biological term
0.86
kinase perturbation
0.84
disease
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3455.16   (req: < 5)
Gene RIFs: 609   (req: <= 3)
Antibodies: 1455   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3455.16   (req: >= 5)
Gene RIFs: 609   (req: > 3)
Antibodies: 1455   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein measurement
1
1
1
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein measurement
1
56.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galectin 3
VGNC:48879
744038
Macaque
galectin 3
697290
Mouse
MGI:96778
16854
Rat
RGD:69356
83781
Dog
galectin 3
VGNC:42648
404021
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galectin 3
Macaque
galectin 3
Mouse
Rat
Dog
galectin 3
Protein Structure (56 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P17931-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 56
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Advanced glycosylation endproduct receptor signaling (R-HSA-879415)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Advanced glycosylation endproduct receptor signaling
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Advanced glycosylation endproduct receptor signaling
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Innate Immune System
Gene Ontology Terms (50)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
ARUK-UCL
Protein-Protein Interactions (310)
1 – 10 of 310
SDK1
Tbio
Novelty: 0.05094526
p_int: 0.999999932
p_ni: 1.3e-8
p_wrong: 5.5e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
CSPG4
Tbio
Novelty: 0.0038499
p_int: 0.999999648
p_ni: 3.24e-7
p_wrong: 2.7e-8
Score: 0.63
Data Source: BioPlex,STRINGDB
PTPRJ
Tbio
Family: Enzyme
Novelty: 0.00786921
p_int: 0.999999223
p_ni: 2.31e-7
p_wrong: 5.47e-7
Score: 0.299
Data Source: BioPlex,STRINGDB
SLC12A6
Tbio
Family: Transporter
Novelty: 0.0132619
p_int: 0.999999147
p_ni: 8.53e-7
Score: 0.297
Data Source: BioPlex,STRINGDB
LAMA1
Tbio
Novelty: 0.00852401
p_int: 0.999998928
p_ni: 0.000001062
p_wrong: 1e-8
Score: 0.6
Data Source: BioPlex,STRINGDB
SDK2
Tdark
Novelty: 0.08867136
p_int: 0.999998879
p_ni: 0.00000112
Data Source: BioPlex
KIAA1549
Tbio
Novelty: 0.01224835
p_int: 0.999998723
p_ni: 3e-9
p_wrong: 0.000001274
Score: 0.251
Data Source: BioPlex,STRINGDB
ITGA1
Tbio
Novelty: 0.00545805
p_int: 0.999998433
p_ni: 0.00000155
p_wrong: 1.7e-8
Score: 0.351
Data Source: BioPlex,STRINGDB
LAMA4
Tbio
Novelty: 0.01288371
p_int: 0.999998431
p_ni: 0.000001569
Score: 0.235
Data Source: BioPlex,STRINGDB
COLEC12
Tbio
Novelty: 0.02882427
p_int: 0.999989813
p_ni: 0.000010187
Score: 0.237
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3455.16

PubMed score by year
PubTator Score  1911.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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