Protein Summary
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition doma ...more
- ENST00000254301
- ENSP00000254301
- ENSG00000131981
- MAC2
- L31
- GAL3
- MAC2
- CBP35
- GALBP
- GALIG
- LGALS2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 1 | ||
biological process | 0.93 | ||
biological term | 0.86 | ||
kinase perturbation | 0.84 | ||
disease | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3586.84 (req: < 5)
Gene RIFs: 609 (req: <= 3)
Antibodies: 1455 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3586.84 (req: >= 5)
Gene RIFs: 609 (req: > 3)
Antibodies: 1455 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 38
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (38)
Protein-Protein Interactions (310)
SDK1
Novelty: 0.05094526
p_int: 0.999999932
p_ni: 1.3e-8
p_wrong: 5.5e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
CSPG4
Novelty: 0.0038499
p_int: 0.999999648
p_ni: 3.24e-7
p_wrong: 2.7e-8
Score: 0.63
Data Source: BioPlex,STRINGDB
PTPRJ
Family: Enzyme
Novelty: 0.00786921
p_int: 0.999999223
p_ni: 2.31e-7
p_wrong: 5.47e-7
Score: 0.299
Data Source: BioPlex,STRINGDB
SLC12A6
Family: Transporter
Novelty: 0.0132619
p_int: 0.999999147
p_ni: 8.53e-7
Score: 0.297
Data Source: BioPlex,STRINGDB
LAMA1
Novelty: 0.00852401
p_int: 0.999998928
p_ni: 0.000001062
p_wrong: 1e-8
Score: 0.6
Data Source: BioPlex,STRINGDB
KIAA1549
Novelty: 0.01224835
p_int: 0.999998723
p_ni: 3e-9
p_wrong: 0.000001274
Score: 0.251
Data Source: BioPlex,STRINGDB
ITGA1
Novelty: 0.00545805
p_int: 0.999998433
p_ni: 0.00000155
p_wrong: 1.7e-8
Score: 0.351
Data Source: BioPlex,STRINGDB
LAMA4
Novelty: 0.01288371
p_int: 0.999998431
p_ni: 0.000001569
Score: 0.235
Data Source: BioPlex,STRINGDB
COLEC12
Novelty: 0.02882427
p_int: 0.999989813
p_ni: 0.000010187
Score: 0.237
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (32)
Reactome (11)
PathwayCommons (2)
WikiPathways (19)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Advanced glycosylation endproduct receptor signaling | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Advanced glycosylation endproduct receptor signaling | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Immune System | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (50)
Functions (8)
Components (15)
Processes (27)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred by Curator (IC) | ARUK-UCL | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
galectin-3 measurement | 1 | 2 | 2 | 95.7 | |||||
mean platelet volume | 2 | 2 | 2 | 87.2 | |||||
protein measurement | 1 | 1 | 1 | 53.6 | |||||
red blood cell distribution width | 1 | 1 | 1 | 8.3 | |||||
self reported educational attainment | 1 | 1 | 1 | 0.6 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
galectin-3 measurement | 2 | 95.7 | |||||
mean platelet volume | 2 | 87.2 | |||||
protein measurement | 1 | 53.6 | |||||
red blood cell distribution width | 1 | 8.3 | |||||
self reported educational attainment | 1 | 0.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | galectin 3 | VGNC:48879 | 744038 | |||||
Macaque | galectin 3 | 697290 | ||||||
Mouse | MGI:96778 | 16854 | ||||||
Rat | RGD:69356 | 83781 | ||||||
Dog | galectin 3 | VGNC:42648 | 404021 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | galectin 3 | |||||
Macaque | galectin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | galectin 3 | |||||
Publication Statistics
PubMed Score 3586.84
PubMed score by year
PubTator Score 1911.76
PubTator score by year
Related Publications
Text Mined References (675)
GeneRif Annotations (609)
Items per page:
0 of 0
PMID | Year | Title |
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