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Tbio
CR1
Complement receptor type 1

Protein Summary
Description
Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728). (Microbial infection) Acts as a receptor for Epstein-Barr virus. This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367051
  • ENSP00000356018
  • ENSG00000203710
  • ENST00000367053
  • ENSP00000356020
  • ENST00000400960
  • ENSP00000383744

Symbol
  • C3BR
  • KN
  • C3BR
  • C4BR
  • CD35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.89
cell type or tissue
0.85
phenotype
0.83
biological process
0.82
disease
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 771.49   (req: < 5)
Gene RIFs: 139   (req: <= 3)
Antibodies: 1100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 771.49   (req: >= 5)
Gene RIFs: 139   (req: > 3)
Antibodies: 1100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0