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Tbio
CR1
Complement receptor type 1

Protein Summary
Description
Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728). (Microbial infection) Acts as a receptor for Epstein-Barr virus. This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367051
  • ENSP00000356018
  • ENSG00000203710
  • ENST00000367053
  • ENSP00000356020
  • ENST00000400960
  • ENSP00000383744

Symbol
  • C3BR
  • KN
  • C3BR
  • C4BR
  • CD35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.89
cell type or tissue
0.85
phenotype
0.83
biological process
0.82
disease
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 579.95   (req: < 5)
Gene RIFs: 139   (req: <= 3)
Antibodies: 1100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 579.95   (req: >= 5)
Gene RIFs: 139   (req: > 3)
Antibodies: 1100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
5
0
1.2
98.7
family history of Alzheimer’s disease
2
3
0
4.9
96.5
blood sedimentation
1
1
1
88.7
late-onset Alzheimers disease
1
1
0
1.2
64
hematocrit
1
1
1
54.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
98.7
family history of Alzheimer’s disease
0
4.9
96.5
blood sedimentation
1
88.7
late-onset Alzheimers disease
0
1.2
64
hematocrit
1
54.8
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement component 3b/4b receptor 1
VGNC:11309
449643
Dog
complement C3b/C4b receptor 1 like
102157092
Horse
complement C3b/C4b receptor 1 (Knops blood group) [Source:HGNC Symbol;Acc:HGNC:2334]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement component 3b/4b receptor 1
Dog
complement C3b/C4b receptor 1 like
Horse
complement C3b/C4b receptor 1 (Knops blood group) [Source:HGNC Symbol;Acc:HGNC:2334]
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Complement cascade
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Innate Immune System
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (96)
1 – 10 of 96
C3
Tbio
Novelty: 0.00019115
Score: 0.997
Data Source: Reactome,STRINGDB
C4B
Tbio
Novelty: 0.00068357
Score: 0.991
Data Source: Reactome,STRINGDB
C4A
Tbio
Novelty: 0.00062793
Score: 0.99
Data Source: Reactome,STRINGDB
CFB
Tchem
Novelty: 0.00102672
Score: 0.946
Data Source: Reactome,STRINGDB
CFI
Tbio
Novelty: 0.00271423
Score: 0.944
Data Source: Reactome,STRINGDB
C2
Tbio
Novelty: 0.00974862
Score: 0.921
Data Source: Reactome,STRINGDB
CD46
Tbio
Novelty: 0.00098341
Score: 0.921
Data Source: STRINGDB
CBFB
Tchem
Family: TF
Novelty: 0.04825679
Score: 0.9
Data Source: STRINGDB
RUNX1
Tbio
Family: TF
Novelty: 0.0085181
Score: 0.9
Data Source: STRINGDB
C5AR1
Tchem
Family: GPCR
Novelty: 0.00188281
Score: 0.828
Data Source: STRINGDB
Publication Statistics
PubMed Score  579.95

PubMed score by year
PubTator Score  1444.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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