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Tchem
XBP1
X-box-binding protein 1

Protein Summary
Description
Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216037
  • ENSP00000216037
  • ENSG00000100219
  • ENST00000344347
  • ENSP00000343155
  • ENST00000611155
  • ENSP00000481170

Symbol
  • TREB5
  • XBP2
  • XBP2
  • TREB5
  • XBP-1
  • TREB-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
0.99
small molecule perturbation
0.92
virus perturbation
0.92
transcription factor binding site profile
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1193.32   (req: < 5)
Gene RIFs: 192   (req: <= 3)
Antibodies: 662   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1193.32   (req: >= 5)
Gene RIFs: 192   (req: > 3)
Antibodies: 662   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 97
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
77.3
1
1
0
1.2
77.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
77.3
0
1.2
77.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
X-box binding protein 1
VGNC:12945
458735
Macaque
X-box binding protein 1
713863
Mouse
MGI:98970
22433
Rat
RGD:1303073
289754
Dog
X-box binding protein 1
477532
Species
Name
OMA
EggNOG
Inparanoid
Chimp
X-box binding protein 1
Macaque
X-box binding protein 1
Mouse
Rat
Dog
X-box binding protein 1
Pathways (202)
ATF6 (ATF6-alpha) activates chaperone genes (R-HSA-381183)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF6 (ATF6-alpha) activates chaperone genes
Reactome
ATF6 (ATF6-alpha) activates chaperones
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
ATF6 (ATF6-alpha) activates chaperone genes
ATF6 (ATF6-alpha) activates chaperones
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
Gene Ontology Terms (103)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (188)
1 – 10 of 188
CROCC
Tbio
Novelty: 0.03718561
p_int: 0.999990281
p_ni: 3.23e-7
p_wrong: 0.000009396
Score: 0.383
Data Source: BioPlex,STRINGDB
CCDC102B
Tdark
Novelty: 0.28075569
p_int: 0.969736671
p_ni: 1.9e-8
p_wrong: 0.03026331
Score: 0.189
Data Source: BioPlex,STRINGDB
ATF6
Tbio
Family: TF
Novelty: 0.00149266
Score: 0.991
Data Source: STRINGDB
ATF4
Tbio
Family: TF
Novelty: 0.00253408
Score: 0.988
Data Source: STRINGDB
ERN1
Tchem
Family: Kinase
Novelty: 0.00141922
Score: 0.985
Data Source: STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
Score: 0.977
Data Source: STRINGDB
DDIT3
Tchem
Family: TF
Novelty: 0.00116135
Score: 0.975
Data Source: STRINGDB
DDIT3
Tbio
Novelty: 0.00116135
Score: 0.975
Data Source: STRINGDB
ATF3
Tbio
Family: TF
Novelty: 0.00164508
Score: 0.928
Data Source: STRINGDB
ATF6B
Tbio
Family: TF
Novelty: 0.07061573
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  1193.32

PubMed score by year
PubTator Score  610.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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