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Tbio
PFKL
ATP-dependent 6-phosphofructokinase, liver type

Protein Summary
Description
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349048
  • ENSP00000269848
  • ENSG00000141959

Symbol
  • PFK-B
  • PFK-L
  • ATP-PFK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
disease perturbation
0.87
transcription factor perturbation
0.84
interacting protein
0.76
hub protein
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.01   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.01   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
27
hemoglobin measurement
1
1
1
19.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
27
hemoglobin measurement
1
19.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphofructokinase, liver type
VGNC:7549
458602
Mouse
MGI:97547
18641
Rat
RGD:3311
25741
Dog
phosphofructokinase, liver type
VGNC:44446
487797
Horse
phosphofructokinase, liver type
VGNC:21341
100056927
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphofructokinase, liver type
Mouse
Rat
Dog
phosphofructokinase, liver type
Horse
phosphofructokinase, liver type
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P17858-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Glucose metabolism (R-HSA-70326)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Glucose metabolism
Glycolysis
Immune System
Innate Immune System
Metabolism
Gene Ontology Terms (26)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (135)
1 – 10 of 135
PFKP
Tbio
Family: Kinase
Novelty: 0.00808684
p_int: 0.99900033
p_ni: 0.00099967
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
TFR2
Tbio
Family: Enzyme
Novelty: 0.00480264
p_int: 0.762626566
p_ni: 0.237373434
Score: 0.365
Data Source: BioPlex,STRINGDB
PFKM
Tbio
Family: Kinase
Novelty: 0.00217816
Score: 0.994
Data Source: Reactome,STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.991
Data Source: STRINGDB
ALDOA
Tbio
Family: Enzyme
Novelty: 0.00517474
Score: 0.978
Data Source: STRINGDB
ALDOC
Tbio
Family: Enzyme
Novelty: 0.01552954
Score: 0.977
Data Source: STRINGDB
ALDOB
Tbio
Family: Enzyme
Novelty: 0.00856695
Score: 0.976
Data Source: STRINGDB
TALDO1
Tbio
Family: Enzyme
Novelty: 0.00208619
Score: 0.961
Data Source: STRINGDB
TKT
Tchem
Family: Enzyme
Novelty: 0.00333936
Score: 0.949
Data Source: STRINGDB
FBP2
Tbio
Family: Enzyme
Novelty: 0.00854851
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score  157.01

PubMed score by year
PubTator Score  47.34

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer