PFKL
ATP-dependent 6-phosphofructokinase, liver type
Protein Summary
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
- ENST00000349048
- ENSP00000269848
- ENSG00000141959
- PFK-B
- PFK-L
- ATP-PFK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
disease perturbation | 0.87 | ||
transcription factor perturbation | 0.84 | ||
interacting protein | 0.76 | ||
hub protein | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 160.18 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 301 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 160.18 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 301 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (135)
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (30)
Reactome (7)
KEGG (12)
PathwayCommons (5)
UniProt (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Glucose metabolism | ||||
Reactome | Glycolysis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glucose metabolism | ||||
Glycolysis | ||||
Immune System | ||||
Innate Immune System | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (9)
Components (7)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
Addison disease | 1 | 2 | 0 | 2.8 | 88.2 | ||||
eosinophil count | 3 | 2 | 3 | 85.1 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 2 | 82.2 | |||||
HbA1c measurement | 1 | 3 | 3 | 67.4 | |||||
2 | 1 | 0 | 1.6 | 61.4 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
Addison disease | 0 | 2.8 | 88.2 | ||||
eosinophil count | 3 | 85.1 | |||||
eosinophil percentage of leukocytes | 2 | 82.2 | |||||
HbA1c measurement | 3 | 67.4 | |||||
0 | 1.6 | 61.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phosphofructokinase, liver type | VGNC:7549 | 458602 | |||||
Mouse | MGI:97547 | 18641 | ||||||
Rat | RGD:3311 | 25741 | ||||||
Dog | phosphofructokinase, liver type | VGNC:44446 | 487797 | |||||
Horse | phosphofructokinase, liver type | VGNC:21341 | 100056927 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phosphofructokinase, liver type | |||||
Mouse | ||||||
Rat | ||||||
Dog | phosphofructokinase, liver type | |||||
Horse | phosphofructokinase, liver type | |||||
Publication Statistics
PubMed Score 160.18
PubMed score by year
PubTator Score 47.34
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (48)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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