Tbio PFKL ATP-dependent 6-phosphofructokinase, liver type

Protein Summary

Description

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• P17858
• Q96A64
• Q96IH4
• Q9BR91
• ATP-PFK

Gene Name

• PFKL

Ensembl ID

• ENST00000349048
• ENSP00000269848
• ENSG00000141959

Symbol

• PFK-B
• PFK-L
• ATP-PFK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
disease perturbation	0.87
transcription factor perturbation	0.84
interacting protein	0.76
hub protein	0.75

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Carbohydrate Kinase / Atp-dependent 6-phosphofructokinase, Liver Type

DTO Classes

Protein / Kinase / Non-protein Kinase / Carbohydrate Kinase / Phosphofructokinase Type A (Pfka) Family / Atp-dependent Pfk Group I Subfamily / Eukaryotic Two Domain Clade "E" Sub-subfamily / Atp-dependent 6-phosphofructokinase, Liver Type

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.36   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 301   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.36   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0