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Tbio
DDX5
Probable ATP-dependent RNA helicase DDX5

Protein Summary
Description
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225792
  • ENSP00000225792
  • ENSG00000108654
  • ENST00000450599
  • ENSP00000403085

Symbol
  • G17P1
  • HELR
  • HLR1
  • p68
  • HLR1
  • G17P1
  • HUMP68
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
molecular function
1
transcription factor binding site profile
0.99
disease perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.49   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 442   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.49   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 442   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
1
1
45
vital capacity
1
1
1
22.7
1
1
0
1
17.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
45
vital capacity
1
22.7
0
1
17.2
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Metabolism of RNA
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent gene expression
Metabolism of RNA
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (44)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (504)
1 – 10 of 504
DDX17
Tbio
Family: Enzyme
Novelty: 0.00462781
p_int: 0.897956328
p_ni: 0.102043672
Score: 0.75
Data Source: BioPlex,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.998
Data Source: STRINGDB
DHX15
Tbio
Family: Enzyme
Novelty: 0.0134377
Score: 0.995
Data Source: STRINGDB
DROSHA
Tbio
Family: Enzyme
Novelty: 0.00107123
Score: 0.989
Data Source: STRINGDB
SNW1
Tbio
Novelty: 0.01423797
Score: 0.987
Data Source: STRINGDB
DHX9
Tbio
Family: Enzyme
Novelty: 0.00130907
Score: 0.986
Data Source: STRINGDB
DHX38
Tbio
Family: Enzyme
Novelty: 0.01939445
Score: 0.985
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01273351
Score: 0.985
Data Source: STRINGDB
MTREX
Tbio
Novelty: 0.01358024
Score: 0.984
Data Source: STRINGDB
HNRNPA0
Tbio
Novelty: 0.10233768
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  176.49

PubMed score by year
PubTator Score  103.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer