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Tbio
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Endoglin

Protein Summary
Description
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344849
  • ENSP00000341917
  • ENSG00000106991
  • ENST00000373203
  • ENSP00000362299

Symbol
  • END
  • END
  • HHT1
  • ORW1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
biological process
0.95
molecular function
0.93
transcription factor perturbation
0.74
biological term
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2672.05   (req: < 5)
Gene RIFs: 382   (req: <= 3)
Antibodies: 2186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2672.05   (req: >= 5)
Gene RIFs: 382   (req: > 3)
Antibodies: 2186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (214)
ACVRL1
Tchem
Family:  Kinase
Novelty:  0.00310167
Score:  0.993
Data Source:  STRINGDB
TGFBR1
Tchem
Family:  Kinase
Novelty:  0.00081645
Score:  0.989
Data Source:  STRINGDB
GDF2
Tbio
Novelty:  0.00433233
Score:  0.989
Data Source:  STRINGDB
TGFB1
Tbio
Novelty:  0.0001299
Score:  0.982
Data Source:  STRINGDB
BMPR2
Tchem
Family:  Kinase
Novelty:  0.00155912
Score:  0.977
Data Source:  STRINGDB
TGFBR2
Tchem
Family:  Kinase
Novelty:  0.00085381
Score:  0.973
Data Source:  STRINGDB
TGFB3
Tbio
Novelty:  0.00068568
Score:  0.966
Data Source:  STRINGDB
ACVR2A
Tchem
Family:  Kinase
Novelty:  0.0063932
Score:  0.963
Data Source:  STRINGDB
SMAD9
Tbio
Family:  TF
Novelty:  0.00285887
Score:  0.96
Data Source:  STRINGDB
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
Score:  0.956
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: netpath
TGF_beta_Receptor
PathwayCommons: pid
ALK1 signaling events
PathwayCommons: pid
HIF-1-alpha transcription factor network
Name
Explore in Pharos
Explore in Source
TGF_beta_Receptor
ALK1 signaling events
HIF-1-alpha transcription factor network
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (76)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
3
3
93.9
hematocrit
3
2
3
86.8
monocyte percentage of leukocytes
2
2
2
72.8
neutrophil percentage of leukocytes
1
1
1
54.4
granulocyte percentage of myeloid white cells
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
93.9
hematocrit
3
86.8
monocyte percentage of leukocytes
2
72.8
neutrophil percentage of leukocytes
1
54.4
granulocyte percentage of myeloid white cells
1
45.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endoglin
VGNC:4681
741046
Mouse
MGI:95392
13805
Rat
RGD:1593188
497010
Dog
endoglin
VGNC:40362
609166
Horse
endoglin
VGNC:17578
100070421
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endoglin
Mouse
Rat
Dog
endoglin
Horse
endoglin
Publication Statistics
PubMed Score 2672.05
PubMed score by year
PubTator Score 1674.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title