Protein Summary
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates ...more
- ENST00000344849
- ENSP00000341917
- ENSG00000106991
- ENST00000373203
- ENSP00000362299
- END
- END
- HHT1
- ORW1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.98 | ||
biological process | 0.95 | ||
molecular function | 0.93 | ||
transcription factor perturbation | 0.74 | ||
biological term | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2672.05 (req: < 5)
Gene RIFs: 382 (req: <= 3)
Antibodies: 2186 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2672.05 (req: >= 5)
Gene RIFs: 382 (req: > 3)
Antibodies: 2186 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 69
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (214)
Nearest Tclin Targets
Pathways (5)
PathwayCommons (3)
WikiPathways (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: netpath | TGF_beta_Receptor | ||||
PathwayCommons: pid | ALK1 signaling events | ||||
PathwayCommons: pid | HIF-1-alpha transcription factor network | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
TGF_beta_Receptor | ||||
ALK1 signaling events | ||||
HIF-1-alpha transcription factor network | ||||
Viral Interactions (0)
Gene Ontology Terms (76)
Functions (11)
Components (7)
Processes (58)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hemoglobin measurement | 3 | 3 | 3 | 93.9 | |||||
hematocrit | 3 | 2 | 3 | 86.8 | |||||
monocyte percentage of leukocytes | 2 | 2 | 2 | 72.8 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 54.4 | |||||
granulocyte percentage of myeloid white cells | 1 | 1 | 1 | 45.7 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hemoglobin measurement | 3 | 93.9 | |||||
hematocrit | 3 | 86.8 | |||||
monocyte percentage of leukocytes | 2 | 72.8 | |||||
neutrophil percentage of leukocytes | 1 | 54.4 | |||||
granulocyte percentage of myeloid white cells | 1 | 45.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | endoglin | VGNC:4681 | 741046 | |||||
Mouse | MGI:95392 | 13805 | ||||||
Rat | RGD:1593188 | 497010 | ||||||
Dog | endoglin | VGNC:40362 | 609166 | |||||
Horse | endoglin | VGNC:17578 | 100070421 | |||||
Publication Statistics
PubMed Score 2672.05
PubMed score by year
PubTator Score 1674.18
PubTator score by year
Related Publications
Text Mined References (429)
GeneRif Annotations (382)
Items per page:
0 of 0
PMID | Year | Title |
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