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Tbio
TAT
Tyrosine aminotransferase

Protein Summary
Description
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible cognitive disability. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355962
  • ENSP00000348234
  • ENSG00000198650
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.7
chemical
0.67
disease
0.64
small molecule perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1221.55   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1221.55   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
4
5
87.4
total cholesterol measurement
2
3
4
82.2
apolipoprotein B measurement
1
2
2
69.3
sex hormone-binding globulin measurement
3
2
3
38.8
pulse pressure measurement
1
1
1
37.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
87.4
total cholesterol measurement
4
82.2
apolipoprotein B measurement
2
69.3
sex hormone-binding globulin measurement
3
38.8
pulse pressure measurement
1
37.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tyrosine aminotransferase
VGNC:13794
454227
Macaque
tyrosine aminotransferase
708005
Mouse
MGI:98487
234724
Rat
RGD:3820
24813
Dog
tyrosine aminotransferase
VGNC:53455
479665
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tyrosine aminotransferase
Macaque
tyrosine aminotransferase
Mouse
Rat
Dog
tyrosine aminotransferase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P17735-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome
HIV Infection
Reactome
HIV Life Cycle
Reactome
HIV Transcription Elongation
Name
Explore in Pharos
Explore in Source
Disease
Formation of HIV-1 elongation complex containing HIV-1 Tat
HIV Infection
HIV Life Cycle
HIV Transcription Elongation
Protein-Protein Interactions (107)
1 – 10 of 107
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.919920863
p_ni:  0.080064304
p_wrong:  0.000014833
Score:  0.323
Data Source:  BioPlex,STRINGDB
HPD
Tclin
Family:  Enzyme
Novelty:  0.00515372
Score:  0.994
Data Source:  STRINGDB
PAH
Tclin
Family:  Enzyme
Novelty:  0.00337068
Score:  0.978
Data Source:  STRINGDB
GOT2
Tbio
Family:  Enzyme
Novelty:  0.00054023
Score:  0.941
Data Source:  STRINGDB
DDC
Tclin
Family:  Enzyme
Novelty:  0.0012284
Score:  0.935
Data Source:  STRINGDB
TH
Tclin
Family:  Enzyme
Novelty:  0.00025719
Score:  0.931
Data Source:  STRINGDB
GOT1
Tbio
Family:  Enzyme
Novelty:  0.00448817
Score:  0.93
Data Source:  STRINGDB
MAT1A
Tbio
Family:  Enzyme
Novelty:  0.00384796
Score:  0.928
Data Source:  STRINGDB
MAT2A
Tchem
Family:  Enzyme
Novelty:  0.00667707
Score:  0.923
Data Source:  STRINGDB
ADI1
Tbio
Family:  Enzyme
Novelty:  0.00908955
Score:  0.921
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1221.55

PubMed score by year
PubTator Score  239.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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