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Tchem
AMD1
S-adenosylmethionine decarboxylase proenzyme

Protein Classes
Protein Summary
Description
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368885
  • ENSP00000357880
  • ENSG00000123505

Symbol
  • AMD
  • AMD
  • SAMDC
  • ADOMETDC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
kinase perturbation
0.95
disease perturbation
0.9
transcription factor binding site profile
0.84
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1707.31   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1707.31   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (25)
1 – 5 of 25
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of polyamines
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Metabolism of polyamines
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (101)
1 – 10 of 101
CLEC11A
Tbio
Novelty: 0.01702243
p_int: 0.999421323
p_ni: 0.000578677
Data Source: BioPlex
BMP15
Tbio
Novelty: 0.00426631
p_int: 0.999389016
p_ni: 0.000610984
Score: 0.204
Data Source: BioPlex,STRINGDB
SSX2
Tbio
Novelty: 0.00354436
p_int: 0.997901358
p_ni: 0.002098642
Data Source: BioPlex
DKKL1
Tbio
Novelty: 0.00579782
p_int: 0.994198599
p_ni: 0.005801401
Score: 0.159
Data Source: BioPlex,STRINGDB
POLR2M
Tbio
Family: Enzyme
Novelty: 0.10421601
p_int: 0.992945776
p_ni: 0.007054224
Data Source: BioPlex
POP4
Tbio
Family: Enzyme
Novelty: 0.02434459
p_int: 0.987722375
p_ni: 0.012277625
Data Source: BioPlex
FBXO4
Tbio
Novelty: 0.07227685
p_int: 0.984035726
p_ni: 0.015964256
p_wrong: 1.8e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
MISP
Tbio
Novelty: 0.01696113
p_int: 0.979838303
p_ni: 0.020161697
Data Source: BioPlex
SHC4
Tbio
Novelty: 0.04557539
p_int: 0.979799393
p_ni: 0.020200607
Score: 0.194
Data Source: BioPlex,STRINGDB
DOK3
Tbio
Novelty: 0.02242601
p_int: 0.979600045
p_ni: 0.020399955
Score: 0.173
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1707.31

PubMed score by year
PubTator Score  147.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer