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Tchem
AMD1
S-adenosylmethionine decarboxylase proenzyme

Protein Classes
Protein Summary
Description
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368885
  • ENSP00000357880
  • ENSG00000123505

Symbol
  • AMD
  • AMD
  • SAMDC
  • ADOMETDC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
kinase perturbation
0.95
disease perturbation
0.9
transcription factor binding site profile
0.84
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 445.21   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 445.21   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (11)
1 – 10 of 11
CHEMBL517131
Rendered image for CHEMBL517131
CHEMBL510356
Rendered image for CHEMBL510356
CHEMBL461970
Rendered image for CHEMBL461970
CHEMBL461779
Rendered image for CHEMBL461779
CHEMBL460719
Rendered image for CHEMBL460719
CHEMBL453372
Rendered image for CHEMBL453372
CHEMBL517593
Rendered image for CHEMBL517593
CHEMBL462656
Rendered image for CHEMBL462656
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
12.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
12.6
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosylmethionine decarboxylase 1
VGNC:2639
472092
Macaque
adenosylmethionine decarboxylase 1
698042
Mouse
MGI:88004
11702
Mouse
MGI:1333111
100041585
Rat
RGD:2104
81640
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosylmethionine decarboxylase 1
Macaque
adenosylmethionine decarboxylase 1
Mouse
Mouse
Rat
Protein Structure (25 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P17707-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 25
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of polyamines
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Metabolism of polyamines
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (101)
1 – 10 of 101
CLEC11A
Tbio
Novelty:  0.03060601
p_int:  0.999421323
p_ni:  0.000578677
Data Source:  BioPlex
BMP15
Tbio
Novelty:  0.00364888
p_int:  0.999389016
p_ni:  0.000610984
Score:  0.204
Data Source:  BioPlex,STRINGDB
SSX2
Tbio
Novelty:  0.00227167
p_int:  0.997901358
p_ni:  0.002098642
Data Source:  BioPlex
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.994198599
p_ni:  0.005801401
Score:  0.159
Data Source:  BioPlex,STRINGDB
POLR2M
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.992945776
p_ni:  0.007054224
Data Source:  BioPlex
POP4
Tbio
Family:  Enzyme
Novelty:  0.01072287
p_int:  0.987722375
p_ni:  0.012277625
Data Source:  BioPlex
FBXO4
Tbio
Novelty:  0.06891705
p_int:  0.984035726
p_ni:  0.015964256
p_wrong:  1.8e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
MISP
Tbio
Novelty:  0.02030151
p_int:  0.979838303
p_ni:  0.020161697
Data Source:  BioPlex
SHC4
Tbio
Novelty:  0.04623367
p_int:  0.979799393
p_ni:  0.020200607
Score:  0.194
Data Source:  BioPlex,STRINGDB
DOK3
Tbio
Novelty:  0.06212348
p_int:  0.979600045
p_ni:  0.020399955
Score:  0.173
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  445.21

PubMed score by year
PubTator Score  147.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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