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Tchem
PTPN2
Tyrosine-protein phosphatase non-receptor type 2

Protein Summary
Description
Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signali ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309660
  • ENSP00000311857
  • ENSG00000175354
  • ENST00000327283
  • ENSP00000320298
  • ENST00000353319
  • ENSP00000320546
  • ENST00000591115
  • ENSP00000466936

Symbol
  • PTPT
  • PTN2
  • PTPT
  • TCPTP
  • TC-PTP
  • TCELLPTP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
virus perturbation
1
disease perturbation
0.99
trait
0.93
transcription factor binding site profile
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.13   (req: < 5)
Gene RIFs: 90   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.13   (req: >= 5)
Gene RIFs: 90   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 168
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (168)
CHEMBL4569405
Rendered image for CHEMBL4569405
CHEMBL507502
Rendered image for CHEMBL507502
CHEMBL4175748
Rendered image for CHEMBL4175748
CHEMBL499413
Rendered image for CHEMBL499413
CHEMBL326115
Rendered image for CHEMBL326115
L-(-)-3-phenyl lactic acid
Rendered image for L-(-)-3-phenyl lactic acid
oxalylaminobenzoic acid
Rendered image for oxalylaminobenzoic acid
CHEMBL4164960
Rendered image for CHEMBL4164960
CHEMBL55243
Rendered image for CHEMBL55243
CHEMBL4475724
Rendered image for CHEMBL4475724
Protein-Protein Interactions (128)
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.999997695
p_ni:  0.000002305
Data Source:  BioPlex
COL5A1
Tbio
Novelty:  0.00506815
p_int:  0.999994591
p_ni:  0.000005125
p_wrong:  2.85e-7
Score:  0.455
Data Source:  BioPlex,STRINGDB
B4GAT1
Tbio
Family:  Enzyme
Novelty:  0.14959923
p_int:  0.999987921
p_ni:  0.000012078
p_wrong:  1e-9
Score:  0.151
Data Source:  BioPlex,STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.999902414
p_ni:  0.000092607
p_wrong:  0.00000498
Data Source:  BioPlex
ASGR1
Tbio
Novelty:  0.00209845
p_int:  0.999845072
p_ni:  0.000154861
p_wrong:  6.7e-8
Score:  0.324
Data Source:  BioPlex,STRINGDB
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.999813723
p_ni:  0.000173269
p_wrong:  0.000013007
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.999548269
p_ni:  0.000151122
p_wrong:  0.000300609
Score:  0.448
Data Source:  BioPlex,STRINGDB
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.999353018
p_ni:  0.000117263
p_wrong:  0.000529719
Data Source:  BioPlex
TNFSF8
Tbio
Novelty:  0.01292216
p_int:  0.991008382
p_ni:  0.001431142
p_wrong:  0.007560477
Data Source:  BioPlex
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.978564106
p_ni:  0.00099235
p_wrong:  0.020443544
Data Source:  BioPlex
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
JAK3
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
TYK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
JAK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
JAK1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
Pathways (28)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Reactome
Interleukin-1 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Interleukin-1 family signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (46)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
5
5
93.5
hemoglobin measurement
2
2
2
82.9
4
2
2
1.1
81.3
4
2
0
1.2
80.2
2
1
0
1.2
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
5
93.5
hemoglobin measurement
2
82.9
2
1.1
81.3
0
1.2
80.2
0
1.2
78.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 2
VGNC:9915
455504
Mouse
MGI:97806
19255
Rat
RGD:620710
117063
Dog
protein tyrosine phosphatase, non-receptor type 2
VGNC:45172
490563
Horse
protein tyrosine phosphatase, non-receptor type 2 [Source:HGNC Symbol;Acc:HGNC:9650]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 2
Mouse
Rat
Dog
protein tyrosine phosphatase, non-receptor type 2
Horse
protein tyrosine phosphatase, non-receptor type 2 [Source:HGNC Symbol;Acc:HGNC:9650]
Publication Statistics
PubMed Score 297.13
PubMed score by year
PubTator Score 193.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title