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Tbio
HLA-G
HLA class I histocompatibility antigen, alpha chain G

Protein Summary
Description
Isoform 1: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110, PubMed:27859042). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:1930479 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360323
  • ENSP00000353472
  • ENSG00000204632
  • ENST00000376815
  • ENSP00000366011
  • ENST00000383621
  • ENSP00000373116
  • ENSG00000206506
  • ENST00000383622
  • ENSP00000373117
  • ENST00000415687
  • ENSP00000389969
  • ENSG00000237216
  • ENST00000423011
  • ENSP00000389522
  • ENSG00000233095
  • ENST00000423373
  • ENSP00000405238
  • ENSG00000235346
  • ENST00000428701
  • ENSP00000412927
  • ENST00000428952
  • ENSP00000388176
  • ENSG00000235680
  • ENST00000429890
  • ENSP00000401326
  • ENST00000444098
  • ENSP00000398200
  • ENSG00000230413
  • ENST00000445373
  • ENSP00000416408
  • ENST00000448306
  • ENSP00000413926
  • ENST00000449127
  • ENSP00000408773
  • ENST00000457132
  • ENSP00000410247
  • ENST00000546545
  • ENSP00000447762
  • ENST00000546634
  • ENSP00000447780
  • ENST00000547241
  • ENSP00000448085
  • ENST00000547931
  • ENSP00000448363
  • ENST00000550897
  • ENSP00000449903
  • ENST00000553052
  • ENSP00000449291
  • ENST00000622601
  • ENSP00000479399
  • ENSG00000276051

Symbol
  • HLA-6.0
  • HLAG
  • MHC-G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
virus perturbation
1
protein domain
0.97
cellular component
0.94
disease
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1283.43   (req: < 5)
Gene RIFs: 641   (req: <= 3)
Antibodies: 1368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1283.43   (req: >= 5)
Gene RIFs: 641   (req: > 3)
Antibodies: 1368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (440)
Items per page:
1 – 5 of 440
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
8
0
1.1
92.5
3
8
0
1.1
92.5
3
8
0
1.1
92.5
3
8
0
1.1
92.5
3
8
0
1.1
92.5
Items per page:
1 – 5 of 440
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92.5
0
1.1
92.5
0
1.1
92.5
0
1.1
92.5
0
1.1
92.5
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P17693-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (36)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Protein-Protein Interactions (272)
1 – 10 of 272
HLA-A
Tbio
Novelty:  0.00270731
p_int:  0.99952393
p_ni:  0.00047607
Score:  0.982
Data Source:  BioPlex,STRINGDB
HLA-C
Tbio
Novelty:  0.00698601
p_int:  0.999293414
p_ni:  0.000706586
Score:  0.981
Data Source:  BioPlex,STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
p_int:  0.99820539
p_ni:  0.00179461
Score:  0.982
Data Source:  BioPlex,STRINGDB
HLA-F
Tbio
Novelty:  0.01200285
p_int:  0.997522974
p_ni:  0.002477026
Score:  0.987
Data Source:  BioPlex,STRINGDB
HLA-B
Tbio
Novelty:  0.00790207
p_int:  0.993953561
p_ni:  0.006046439
Score:  0.969
Data Source:  BioPlex,STRINGDB
HLA-E
Tbio
Novelty:  0.00216583
p_int:  0.988282919
p_ni:  0.011717081
Score:  0.969
Data Source:  BioPlex,STRINGDB
PRXL2A
Tchem
Novelty:  0.01336664
p_int:  0.871904658
p_ni:  0.128095342
Score:  0.613
Data Source:  BioPlex,STRINGDB
B2M
Tbio
Novelty:  0.00011248
Score:  0.998
Data Source:  Reactome,STRINGDB
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.998
Data Source:  STRINGDB
LILRB1
Tbio
Novelty:  0.00463824
Score:  0.993
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1283.43

PubMed score by year
PubTator Score  2190.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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