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Tclin
KCNA6
Potassium voltage-gated channel subfamily A member 6

Protein Summary
Description
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305). Potassium channels represent th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280684
  • ENSP00000280684
  • ENSG00000151079

Symbol
  • HBK2
  • KV1.6
  • PPP1R96
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
microRNA
0.79
molecular function
0.79
cell line
0.66
PubMedID
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.03   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.03   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96663
16494
Dog
potassium voltage-gated channel subfamily A member 6
486733
Horse
potassium voltage-gated channel subfamily A member 6
100051577
Cow
potassium voltage-gated channel subfamily A member 6
539714
Opossum
potassium voltage-gated channel subfamily A member 6
100013991
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
potassium voltage-gated channel subfamily A member 6
Horse
potassium voltage-gated channel subfamily A member 6
Cow
potassium voltage-gated channel subfamily A member 6
Opossum
potassium voltage-gated channel subfamily A member 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P17658-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Protein-Protein Interactions (101)
1 – 10 of 101
KCNA3
Tclin
Family: IC
Novelty: 0.00169224
p_int: 0.999997704
p_ni: 2.65e-7
p_wrong: 0.000002031
Score: 0.56
Data Source: BioPlex,STRINGDB
DOLK
Tbio
Family: Enzyme
Novelty: 0.00664639
p_int: 0.999343011
p_ni: 0.000528213
p_wrong: 0.000128776
Score: 0.234
Data Source: BioPlex,STRINGDB
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
p_int: 0.954293242
p_ni: 0.045706674
p_wrong: 8.3e-8
Score: 0.701
Data Source: BioPlex,STRINGDB
GOLM1
Tbio
Novelty: 0.00752112
p_int: 0.949868616
p_ni: 0.050131384
p_wrong: 1e-9
Score: 0.237
Data Source: BioPlex,STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
FAU
Tbio
Novelty: 0.01170009
Score: 0.788
Data Source: STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.587
Data Source: STRINGDB
AMIGO1
Tbio
Novelty: 0.00864791
Score: 0.538
Data Source: STRINGDB
DEPDC7
Tdark
Novelty: 0.28944316
Score: 0.529
Data Source: STRINGDB
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.524
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.03

PubMed score by year
PubTator Score  23.91

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer