You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TYRP1
5,6-dihydroxyindole-2-carboxylic acid oxidase

Protein Classes
Protein Summary
Description
Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity). This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388918
  • ENSP00000373570
  • ENSG00000107165

Symbol
  • CAS2
  • TYRP
  • TYRRP
  • TRP
  • CAS2
  • CATB
  • GP75
  • OCA3
  • TRP1
  • TYRP
  • b-PROTEIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.92
gene perturbation
0.71
cell type or tissue
0.7
tissue sample
0.63
cell line
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 869.49   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 685   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 869.49   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 685   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Melanin biosynthesis (R-HSA-5662702)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Melanin biosynthesis
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Melanin biosynthesis
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (114)
1 – 10 of 114
ZNF431
Tdark
Family: TF
Novelty: 1.42857143
p_int: 0.999812218
p_ni: 0.000187775
p_wrong: 7e-9
Score: 0.689
Data Source: BioPlex,STRINGDB
DCT
Tbio
Family: Enzyme
Novelty: 0.00278157
Score: 0.956
Data Source: STRINGDB
MITF
Tbio
Family: TF
Novelty: 0.00112891
Score: 0.933
Data Source: STRINGDB
TRPC1
Tbio
Family: IC
Novelty: 0.00278663
Score: 0.918
Data Source: STRINGDB
MLANA
Tbio
Novelty: 0.00107146
Score: 0.911
Data Source: STRINGDB
PMEL
Tbio
Novelty: 0.00174298
Score: 0.894
Data Source: STRINGDB
TYR
Tclin
Family: Enzyme
Novelty: 0.00007229
Score: 0.891
Data Source: STRINGDB
SLC45A2
Tbio
Family: Transporter
Novelty: 0.00274342
Score: 0.876
Data Source: STRINGDB
SLC24A5
Tbio
Family: Transporter
Novelty: 0.01966176
Score: 0.875
Data Source: STRINGDB
OCA2
Tbio
Novelty: 0.00300697
Score: 0.856
Data Source: STRINGDB
Publication Statistics
PubMed Score  869.49

PubMed score by year
PubTator Score  300.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: