TYRP1
5,6-dihydroxyindole-2-carboxylic acid oxidase
Protein Summary
Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity). This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]
- ENST00000388918
- ENSP00000373570
- ENSG00000107165
- CAS2
- TYRP
- TYRRP
- TRP
- CAS2
- CATB
- GP75
- OCA3
- TRP1
- TYRP
- b-PROTEIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.92 | ||
gene perturbation | 0.71 | ||
cell type or tissue | 0.7 | ||
tissue sample | 0.63 | ||
cell line | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1733.25 (req: < 5)
Gene RIFs: 54 (req: <= 3)
Antibodies: 685 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1733.25 (req: >= 5)
Gene RIFs: 54 (req: > 3)
Antibodies: 685 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0