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Tbio
TYRP1
5,6-dihydroxyindole-2-carboxylic acid oxidase

Protein Summary
Description
Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity). This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388918
  • ENSP00000373570
  • ENSG00000107165

Symbol
  • CAS2
  • TYRP
  • TYRRP
  • TRP
  • CAS2
  • CATB
  • GP75
  • OCA3
  • TRP1
  • TYRP
  • b-PROTEIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.92
gene perturbation
0.71
cell type or tissue
0.7
tissue sample
0.63
cell line
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1541.6   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 685   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1541.6   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 685   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
ZNF431
Tdark
Family:  TF
Novelty:  1.38008368
p_int:  0.999812218
p_ni:  0.000187775
p_wrong:  7e-9
Score:  0.689
Data Source:  BioPlex,STRINGDB
DCT
Tbio
Family:  Enzyme
Novelty:  0.00411451
Score:  0.956
Data Source:  STRINGDB
MITF
Tchem
Family:  TF
Novelty:  0.00094044
Score:  0.933
Data Source:  STRINGDB
TRPC1
Tbio
Family:  IC
Novelty:  0.00233677
Score:  0.918
Data Source:  STRINGDB
MLANA
Tbio
Novelty:  0.00070835
Score:  0.911
Data Source:  STRINGDB
PMEL
Tbio
Novelty:  0.00116525
Score:  0.894
Data Source:  STRINGDB
TYR
Tclin
Family:  Enzyme
Novelty:  0.00048513
Score:  0.891
Data Source:  STRINGDB
SLC45A2
Tbio
Family:  Transporter
Novelty:  0.00268252
Score:  0.876
Data Source:  STRINGDB
SLC24A5
Tbio
Family:  Transporter
Novelty:  0.01224635
Score:  0.875
Data Source:  STRINGDB
OCA2
Tbio
Novelty:  0.00249611
Score:  0.856
Data Source:  STRINGDB
Pathways (11)
Melanin biosynthesis (R-HSA-5662702)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Melanin biosynthesis
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Melanin biosynthesis
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.2
86.6
hair colour measurement
1
1
1
86
suntan
1
1
1
68.8
eye color
1
1
0
1.4
17.3
1
1
0
1.1
10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.2
86.6
hair colour measurement
1
86
suntan
1
68.8
eye color
0
1.4
17.3
0
1.1
10
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tyrosinase related protein 1
VGNC:10117
464994
Mouse
MGI:98881
22178
Rat
RGD:1593266
298182
Dog
tyrosinase related protein 1
VGNC:48029
403479
Horse
tyrosinase related protein 1
VGNC:24693
100033886
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tyrosinase related protein 1
Mouse
Rat
Dog
tyrosinase related protein 1
Horse
tyrosinase related protein 1
Publication Statistics
PubMed Score 1541.60
PubMed score by year
PubTator Score 300.88
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title