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Tbio
SYN1
Synapsin-1

Protein Summary
Description
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary ne ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295987
  • ENSP00000295987
  • ENSG00000008056
  • ENST00000340666
  • ENSP00000343206

Symbol
  • SYNI
  • SYN1a
  • SYN1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
protein domain
0.99
molecular function
0.93
gene perturbation
0.73
biological term
0.72


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1003.35   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 981   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1003.35   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 981   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
synapsin I
100423092
Mouse
MGI:98460
20964
Rat
RGD:3797
24949
Dog
synapsin I
VGNC:47023
100685486
Horse
synapsin I
VGNC:23796
100146838
Species
Name
OMA
EggNOG
Inparanoid
Macaque
synapsin I
Mouse
Rat
Dog
synapsin I
Horse
synapsin I
Pathways (11)
Dopamine Neurotransmitter Release Cycle (R-HSA-212676)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
Serotonin Neurotransmitter Release Cycle
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Dopamine Neurotransmitter Release Cycle
Neuronal System
Neurotransmitter release cycle
Serotonin Neurotransmitter Release Cycle
Transmission across Chemical Synapses
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (305)
1 – 10 of 305
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.999999249
p_ni: 7.5e-7
Data Source: BioPlex
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.999999218
p_ni: 7.82e-7
Data Source: BioPlex
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.999993682
p_ni: 0.000006318
Data Source: BioPlex
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.999941126
p_ni: 0.000058864
p_wrong: 9e-9
Data Source: BioPlex
ARMC1
Tbio
Novelty: 0.02018109
p_int: 0.999175447
p_ni: 0.000824553
Score: 0.165
Data Source: BioPlex,STRINGDB
SNAP25
Tclin
Novelty: 0.00148905
Score: 0.986
Data Source: STRINGDB
SYT1
Tbio
Novelty: 0.00176103
Score: 0.984
Data Source: STRINGDB
RAB3A
Tbio
Family: Enzyme
Novelty: 0.0043532
Score: 0.981
Data Source: STRINGDB
VAMP2
Tbio
Novelty: 0.00187736
Score: 0.972
Data Source: STRINGDB
STX1A
Tbio
Novelty: 0.00087207
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  1003.35

PubMed score by year
PubTator Score  432.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer