Tclin NDUFB7 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Protein Summary

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P17568
• Q6ICN9
• Q9UI16

Gene Name

• NDUFB7

Ensembl ID

• ENST00000215565
• ENSP00000215565
• ENSG00000099795

Symbol

• B18
• CI-B18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.78
disease perturbation	0.74
kinase perturbation	0.71
transcription factor binding site profile	0.69
cell line	0.64

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 7

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.66   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.66   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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metformin

NDUFB7Tclin Enzyme

INHIBITOR :

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (203)

Explore Interacting Targets

1 – 10 of 203

• See Interactions on String-DB

NDUFB11

Tclin

Family:  Enzyme

Novelty:  0.0401232

p_int:  0.999999991

p_ni:  6e-9

p_wrong:  4e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFV3

Tclin

Family:  Enzyme

Novelty:  0.15352039

p_int:  0.999999989

p_ni:  1.1e-8

Score:  0.99

Data Source:  BioPlex,STRINGDB

NDUFA7

Tclin

Family:  Enzyme

Novelty:  0.16417588

p_int:  0.999999735

p_ni:  2.65e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFS6

Tclin

Family:  Enzyme

Novelty:  0.07910252

p_int:  0.999999133

p_ni:  8.29e-7

p_wrong:  3.8e-8

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFB3

Tclin

Family:  Enzyme

Novelty:  0.13020753

p_int:  0.99998618

p_ni:  0.00001382

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFA9

Tclin

Family:  Enzyme

Novelty:  0.00637307

p_int:  0.999980874

p_ni:  0.000019118

p_wrong:  8e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFB5

Tclin

Family:  Enzyme

Novelty:  0.0257403

p_int:  0.999963598

p_ni:  0.000036174

p_wrong:  2.28e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFA8

Tclin

Family:  Enzyme

Novelty:  0.05772867

p_int:  0.99971111

p_ni:  0.000273753

p_wrong:  0.000015137

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFS7

Tclin

Family:  Enzyme

Novelty:  0.01562198

p_int:  0.999677539

p_ni:  0.000315503

p_wrong:  0.000006957

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFS5

Tclin

Family:  Enzyme

Novelty:  0.13274675

p_int:  0.998662714

p_ni:  0.001332953

p_wrong:  0.000004333

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (17)

Reactome (5)

KEGG (8)

WikiPathways (4)

Complex I biogenesis (R-HSA-6799198)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Complex I biogenesis	55 targets	R-HSA-6799198
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Respiratory electron transport	101 targets	R-HSA-611105
Reactome	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
Reactome	The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Name	Explore in Pharos	Explore in Source
Complex I biogenesis	55 targets	R-HSA-6799198
Metabolism	2112 targets	R-HSA-1430728
Respiratory electron transport	101 targets	R-HSA-611105
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (4)

Processes (2)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
NADH dehydrogenase (ubiquinone) activity	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (4)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
risk-taking behaviour	EFO_0008579	2	2	2		61.8
urolithiasis	MONDO_0024647	1	1	1		55
glomerular filtration rate	EFO_0005208	2	1	2		18.4
nephrolithiasis	EFO_0004253	1	1	0	1.1	15

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
risk-taking behaviour	EFO_0008579	2		61.8
urolithiasis	MONDO_0024647	1		55
glomerular filtration rate	EFO_0005208	2		18.4
nephrolithiasis	EFO_0004253	0	1.1	15

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Disulfide bond
Electron transport
Lipoprotein
Membrane
Mitochondrion
Mitochondrion inner membrane
Myristate
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
glomerular filtration rate
nephrolithiasis
risk-taking behaviour
urolithiasis

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NADH:ubiquinone oxidoreductase subunit B7	VGNC:6465	468748
Mouse	NADH:ubiquinone oxidoreductase subunit B7	MGI:1914166	66916
Rat	NADH:ubiquinone oxidoreductase subunit B7	RGD:1308550	361385
Dog	NADH:ubiquinone oxidoreductase subunit B7	VGNC:43705	476686
Horse	NADH:ubiquinone oxidoreductase subunit B7	VGNC:20642	100064992

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NADH:ubiquinone oxidoreductase subunit B7
Mouse	NADH:ubiquinone oxidoreductase subunit B7
Rat	NADH:ubiquinone oxidoreductase subunit B7
Dog	NADH:ubiquinone oxidoreductase subunit B7
Horse	NADH:ubiquinone oxidoreductase subunit B7

Publication Statistics

PubMed Score 9.66

PubMed score by year

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PubTator Score 122.88

PubTator score by year

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Related Publications

Text Mined References (17)

GeneRif Annotations (4)

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PMID	Year	Title