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Tbio
ATF7
Cyclic AMP-dependent transcription factor ATF-7

Protein Summary
Description
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000420353
  • ENSP00000399465
  • ENSG00000170653
  • ENST00000456903
  • ENSP00000387406
  • ENST00000548118
  • ENSP00000456858
  • ENST00000548446
  • ENSP00000449938
  • ENST00000591397
  • ENSP00000465192

Symbol
  • ATFA
  • ATFA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
transcription factor binding site profile
0.8
transcription factor perturbation
0.8
protein domain
0.73
transcription factor
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.56   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.56   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
FOSL2
Tbio
Family:  TF
Novelty:  0.00375452
p_int:  0.999999977
p_ni:  2.3e-8
Score:  0.79
Data Source:  BioPlex,STRINGDB
JUNB
Tbio
Family:  TF
Novelty:  0.00841656
p_int:  0.9999998
p_ni:  1.98e-7
p_wrong:  2e-9
Score:  0.906
Data Source:  BioPlex,STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
p_int:  0.999999462
p_ni:  5.38e-7
Score:  0.891
Data Source:  BioPlex,STRINGDB
CEBPG
Tbio
Family:  TF
Novelty:  0.07956633
p_int:  0.99999924
p_ni:  7.59e-7
p_wrong:  2e-9
Score:  0.416
Data Source:  BioPlex,STRINGDB
BATF3
Tbio
Family:  TF
Novelty:  0.01554987
p_int:  0.99999923
p_ni:  7.7e-7
Score:  0.702
Data Source:  BioPlex,STRINGDB
ATF2
Tbio
Family:  TF
Novelty:  0.00457832
p_int:  0.999998982
p_ni:  0.000001006
p_wrong:  1.2e-8
Score:  0.877
Data Source:  BioPlex,STRINGDB
SCGN
Tbio
Novelty:  0.01434518
p_int:  0.99998801
p_ni:  0.00001199
Score:  0.289
Data Source:  BioPlex,STRINGDB
CREB5
Tbio
Family:  TF
Novelty:  0.03857106
p_int:  0.999979475
p_ni:  0.000020525
Score:  0.867
Data Source:  BioPlex,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.999904773
p_ni:  0.000095223
p_wrong:  4e-9
Data Source:  BioPlex
MLLT6
Tdark
Family:  Epigenetic
Novelty:  0.03728427
p_int:  0.999778757
p_ni:  0.000221243
Score:  0.677
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Apoptosis signaling pathway
PathwayCommons: pid
Regulation of retinoblastoma protein
Name
Explore in Pharos
Explore in Source
Apoptosis signaling pathway
Regulation of retinoblastoma protein
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
3
3
92.6
neutrophil count
2
2
2
89.6
body height
2
3
3
87.6
granulocyte percentage of myeloid white cells
1
1
1
75.4
neutrophil percentage of leukocytes
1
1
1
74.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
3
92.6
neutrophil count
2
89.6
body height
3
87.6
granulocyte percentage of myeloid white cells
1
75.4
neutrophil percentage of leukocytes
1
74.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2443472
223922
Rat
RGD:1304940
315333
Dog
activating transcription factor 7
607149
Horse
activating transcription factor 7
100062229
Cow
activating transcription factor 7
541204
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
activating transcription factor 7
Horse
activating transcription factor 7
Cow
activating transcription factor 7
Publication Statistics
PubMed Score 84.56
PubMed score by year
PubTator Score 25.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title