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Tbio
TAL1
T-cell acute lymphocytic leukemia protein 1

Protein Summary
Description
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294339
  • ENSP00000294339
  • ENSG00000162367
  • ENST00000371884
  • ENSP00000360951

Symbol
  • BHLHA17
  • SCL
  • TCL5
  • SCL
  • TCL5
  • tal-1
  • bHLHa17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.97
biological process
0.95
molecular function
0.95
gene perturbation
0.81
PubMedID
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.63   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 671   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.63   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 671   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Gene Ontology Terms (48)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (133)
1 – 10 of 133
LMO2
Tbio
Novelty: 0.00508219
Score: 0.999
Data Source: STRINGDB
LDB1
Tbio
Novelty: 0.00548345
Score: 0.996
Data Source: STRINGDB
GATA1
Tbio
Family: TF
Novelty: 0.0009412
Score: 0.994
Data Source: STRINGDB
GATA2
Tbio
Family: TF
Novelty: 0.00178271
Score: 0.99
Data Source: STRINGDB
TCF3
Tbio
Family: TF
Novelty: 0.00154157
Score: 0.987
Data Source: STRINGDB
GATA3
Tbio
Family: TF
Novelty: 0.00087325
Score: 0.985
Data Source: STRINGDB
LMO1
Tbio
Novelty: 0.02373858
Score: 0.983
Data Source: STRINGDB
TCF12
Tbio
Family: TF
Novelty: 0.00546341
Score: 0.977
Data Source: STRINGDB
MYB
Tbio
Family: TF
Novelty: 0.0010418
Score: 0.967
Data Source: STRINGDB
RUNX1
Tbio
Family: TF
Novelty: 0.00847283
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  272.63

PubMed score by year
PubTator Score  230.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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