TAL1
T-cell acute lymphocytic leukemia protein 1
Protein Classes
Protein Summary
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
- ENST00000294339
- ENSP00000294339
- ENSG00000162367
- ENST00000371884
- ENSP00000360951
- BHLHA17
- SCL
- TCL5
- SCL
- TCL5
- tal-1
- bHLHa17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.97 | ||
biological process | 0.95 | ||
molecular function | 0.95 | ||
gene perturbation | 0.81 | ||
PubMedID | 0.8 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 272.63 (req: < 5)
Gene RIFs: 74 (req: <= 3)
Antibodies: 671 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 272.63 (req: >= 5)
Gene RIFs: 74 (req: > 3)
Antibodies: 671 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 44
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (7)
Reactome (7)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | RUNX1 regulates transcription of genes involved in differentiation of HSCs | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
RUNX1 regulates transcription of genes involved in differentiation of HSCs | ||||
Gene Ontology Terms (48)
Functions (11)
Components (4)
Processes (33)
Items per page:
10
1 – 10 of 11
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (133)
1 – 10 of 133
LMO2
Novelty: 0.00508219
Score: 0.999
Data Source: STRINGDB
LDB1
Novelty: 0.00548345
Score: 0.996
Data Source: STRINGDB
GATA1
Family: TF
Novelty: 0.0009412
Score: 0.994
Data Source: STRINGDB
GATA2
Family: TF
Novelty: 0.00178271
Score: 0.99
Data Source: STRINGDB
TCF3
Family: TF
Novelty: 0.00154157
Score: 0.987
Data Source: STRINGDB
GATA3
Family: TF
Novelty: 0.00087325
Score: 0.985
Data Source: STRINGDB
LMO1
Novelty: 0.02373858
Score: 0.983
Data Source: STRINGDB
TCF12
Family: TF
Novelty: 0.00546341
Score: 0.977
Data Source: STRINGDB
MYB
Family: TF
Novelty: 0.0010418
Score: 0.967
Data Source: STRINGDB
RUNX1
Family: TF
Novelty: 0.00847283
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score 272.63
PubMed score by year
PubTator Score 230.32
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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