TAL1
T-cell acute lymphocytic leukemia protein 1
Protein Summary
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
- ENST00000294339
- ENSP00000294339
- ENSG00000162367
- ENST00000371884
- ENSP00000360951
- BHLHA17
- SCL
- TCL5
- SCL
- TCL5
- tal-1
- bHLHa17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.97 | ||
biological process | 0.95 | ||
molecular function | 0.95 | ||
gene perturbation | 0.81 | ||
PubMedID | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 339.23 (req: < 5)
Gene RIFs: 74 (req: <= 3)
Antibodies: 671 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 339.23 (req: >= 5)
Gene RIFs: 74 (req: > 3)
Antibodies: 671 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 44
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (133)
Nearest Tclin Targets
Pathways (7)
Reactome (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | RUNX1 regulates transcription of genes involved in differentiation of HSCs | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
RUNX1 regulates transcription of genes involved in differentiation of HSCs | ||||
Viral Interactions (0)
Gene Ontology Terms (48)
Functions (11)
Components (4)
Processes (33)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 85.4 | |||||
red blood cell distribution width | 2 | 2 | 2 | 71.4 | |||||
mean platelet volume | 2 | 2 | 2 | 70.1 | |||||
body mass index | 4 | 2 | 4 | 69.6 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 48.3 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 85.4 | |||||
red blood cell distribution width | 2 | 71.4 | |||||
mean platelet volume | 2 | 70.1 | |||||
body mass index | 4 | 69.6 | |||||
mean reticulocyte volume | 1 | 48.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:98480 | 21349 | ||||||
Rat | RGD:1306748 | 313507 | ||||||
Dog | TAL bHLH transcription factor 1, erythroid differentiation factor | VGNC:47096 | 610331 | |||||
Cow | TAL bHLH transcription factor 1, erythroid differentiation factor | VGNC:35588 | 518657 | |||||
Opossum | TAL bHLH transcription factor 1, erythroid differentiation factor | 100023410 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | TAL bHLH transcription factor 1, erythroid differentiation factor | |||||
Cow | TAL bHLH transcription factor 1, erythroid differentiation factor | |||||
Opossum | TAL bHLH transcription factor 1, erythroid differentiation factor | |||||
Publication Statistics
PubMed Score 339.23
PubMed score by year
PubTator Score 230.32
PubTator score by year
Related Publications
Text Mined References (116)
GeneRif Annotations (74)
Items per page:
0 of 0
PMID | Year | Title |
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