Tbio TAL1 T-cell acute lymphocytic leukemia protein 1

Protein Summary

Description

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Uniprot Accession IDs

• P17542
• D3DQ24
• TAL-1

Gene Name

• TAL1

Ensembl ID

• ENST00000294339
• ENSP00000294339
• ENSG00000162367
• ENST00000371884
• ENSP00000360951

Symbol

• BHLHA17
• SCL
• TCL5
• SCL
• TCL5
• tal-1
• bHLHa17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.97
biological process	0.95
molecular function	0.95
gene perturbation	0.81
PubMedID	0.8

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / T-cell Acute Lymphocytic Leukemia Protein 1

Protein / Nucleic Acid Binding / T-cell Acute Lymphocytic Leukemia Protein 1

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / T-cell Acute Lymphocytic Leukemia Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 369.51   (req: < 5)

Gene RIFs: 88   (req: <= 3)

Antibodies: 671   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 369.51   (req: >= 5)

Gene RIFs: 88   (req: > 3)

Antibodies: 671   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0