TAL1
T-cell acute lymphocytic leukemia protein 1
Protein Classes
Protein Summary
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
- ENST00000294339
- ENSP00000294339
- ENSG00000162367
- ENST00000371884
- ENSP00000360951
- BHLHA17
- SCL
- TCL5
- SCL
- TCL5
- tal-1
- bHLHa17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 0.97 | ||
biological process | 0.95 | ||
molecular function | 0.95 | ||
gene perturbation | 0.81 | ||
PubMedID | 0.8 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 339.23 (req: < 5)
Gene RIFs: 74 (req: <= 3)
Antibodies: 671 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 339.23 (req: >= 5)
Gene RIFs: 74 (req: > 3)
Antibodies: 671 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 44
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 85.4 | |||||
red blood cell distribution width | 2 | 2 | 2 | 71.4 | |||||
mean platelet volume | 2 | 2 | 2 | 70.1 | |||||
body mass index | 4 | 2 | 4 | 69.6 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 48.3 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 85.4 | |||||
red blood cell distribution width | 2 | 71.4 | |||||
mean platelet volume | 2 | 70.1 | |||||
body mass index | 4 | 69.6 | |||||
mean reticulocyte volume | 1 | 48.3 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:98480 | 21349 | ||||||
Rat | RGD:1306748 | 313507 | ||||||
Dog | TAL bHLH transcription factor 1, erythroid differentiation factor | VGNC:47096 | 610331 | |||||
Cow | TAL bHLH transcription factor 1, erythroid differentiation factor | VGNC:35588 | 518657 | |||||
Opossum | TAL bHLH transcription factor 1, erythroid differentiation factor | 100023410 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | TAL bHLH transcription factor 1, erythroid differentiation factor | |||||
Cow | TAL bHLH transcription factor 1, erythroid differentiation factor | |||||
Opossum | TAL bHLH transcription factor 1, erythroid differentiation factor | |||||
Protein Structure (2 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (7)
Reactome (7)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | RUNX1 regulates transcription of genes involved in differentiation of HSCs | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
RUNX1 regulates transcription of genes involved in differentiation of HSCs | ||||
Gene Ontology Terms (48)
Functions (11)
Components (4)
Processes (33)
Items per page:
10
1 – 10 of 11
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (133)
1 – 10 of 133
LMO2
Novelty: 0.0038279
Score: 0.999
Data Source: STRINGDB
LDB1
Novelty: 0.01110112
Score: 0.996
Data Source: STRINGDB
GATA1
Family: TF
Novelty: 0.00077901
Score: 0.994
Data Source: STRINGDB
GATA2
Family: TF
Novelty: 0.00153967
Score: 0.99
Data Source: STRINGDB
TCF3
Family: TF
Novelty: 0.00112675
Score: 0.987
Data Source: STRINGDB
GATA3
Family: TF
Novelty: 0.00071141
Score: 0.985
Data Source: STRINGDB
LMO1
Novelty: 0.01670419
Score: 0.983
Data Source: STRINGDB
TCF12
Family: TF
Novelty: 0.00381424
Score: 0.977
Data Source: STRINGDB
MYB
Family: TF
Novelty: 0.00092053
Score: 0.967
Data Source: STRINGDB
RUNX1
Family: TF
Novelty: 0.0085181
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score 339.23
PubMed score by year
PubTator Score 230.32
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|
GWAS Trait
No Header | No Header | ||
|---|---|---|---|
MGI Phenotype
No Header | No Header | ||
|---|---|---|---|