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Tbio
TAL1
T-cell acute lymphocytic leukemia protein 1

Protein Summary
Description
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294339
  • ENSP00000294339
  • ENSG00000162367
  • ENST00000371884
  • ENSP00000360951

Symbol
  • BHLHA17
  • SCL
  • TCL5
  • SCL
  • TCL5
  • tal-1
  • bHLHa17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.97
biological process
0.95
molecular function
0.95
gene perturbation
0.81
PubMedID
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.23   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 671   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.23   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 671   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
85.4
red blood cell distribution width
2
2
2
71.4
mean platelet volume
2
2
2
70.1
body mass index
4
2
4
69.6
mean reticulocyte volume
1
1
1
48.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
85.4
red blood cell distribution width
2
71.4
mean platelet volume
2
70.1
body mass index
4
69.6
mean reticulocyte volume
1
48.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98480
21349
Rat
RGD:1306748
313507
Dog
TAL bHLH transcription factor 1, erythroid differentiation factor
VGNC:47096
610331
Cow
TAL bHLH transcription factor 1, erythroid differentiation factor
VGNC:35588
518657
Opossum
TAL bHLH transcription factor 1, erythroid differentiation factor
100023410
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
TAL bHLH transcription factor 1, erythroid differentiation factor
Cow
TAL bHLH transcription factor 1, erythroid differentiation factor
Opossum
TAL bHLH transcription factor 1, erythroid differentiation factor
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P17542-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Gene Ontology Terms (48)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (133)
1 – 10 of 133
LMO2
Tbio
Novelty:  0.0038279
Score:  0.999
Data Source:  STRINGDB
LDB1
Tbio
Novelty:  0.01110112
Score:  0.996
Data Source:  STRINGDB
GATA1
Tbio
Family:  TF
Novelty:  0.00077901
Score:  0.994
Data Source:  STRINGDB
GATA2
Tbio
Family:  TF
Novelty:  0.00153967
Score:  0.99
Data Source:  STRINGDB
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
Score:  0.987
Data Source:  STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.985
Data Source:  STRINGDB
LMO1
Tbio
Novelty:  0.01670419
Score:  0.983
Data Source:  STRINGDB
TCF12
Tbio
Family:  TF
Novelty:  0.00381424
Score:  0.977
Data Source:  STRINGDB
MYB
Tbio
Family:  TF
Novelty:  0.00092053
Score:  0.967
Data Source:  STRINGDB
RUNX1
Tbio
Family:  TF
Novelty:  0.0085181
Score:  0.967
Data Source:  STRINGDB
Publication Statistics
PubMed Score  339.23

PubMed score by year
PubTator Score  230.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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