Tbio CKMT2 Creatine kinase S-type, mitochondrial

Protein Summary

Description

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P17540
• Q6ICS8
• Q8N1E1

Gene Name

• CKMT2

Ensembl ID

• ENST00000254035
• ENSP00000254035
• ENSG00000131730
• ENST00000424301
• ENSP00000404203
• ENST00000437669
• ENSP00000410289

Symbol

• SMTCK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
protein domain	0.73
cellular component	0.63
gene perturbation	0.53
tissue	0.5

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Amino Acid Kinase / Creatine Kinase S-type, Mitochondrial

DTO Classes

Protein / Kinase / Unclassified Protein / Creatine Kinase S-type, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.87   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 376   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.87   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0