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Tchem
CTRB1
Chymotrypsinogen B

Protein Summary
Description
This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This gene is located adjacent to a related chymotrypsinogen gene. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361017
  • ENSP00000354294
  • ENSG00000168925

Symbol
  • CTRB
  • CTRB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.83
drug
0.75
cell type or tissue
0.59
tissue
0.58
gene perturbation
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.01   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.01   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (41)
Protein-Protein Interactions (46)
CTRB2
Tdark
Family:  Enzyme
Novelty:  0.20557479
p_int:  1
Score:  0.848
Data Source:  BioPlex,STRINGDB
PNMA2
Tbio
Novelty:  0.00162709
p_int:  0.953386062
p_ni:  0.046613937
p_wrong:  1e-9
Score:  0.323
Data Source:  BioPlex,STRINGDB
CPA1
Tchem
Family:  Enzyme
Novelty:  0.00601525
Score:  0.945
Data Source:  STRINGDB
MMP9
Tchem
Family:  Enzyme
Novelty:  0.00008645
Score:  0.922
Data Source:  STRINGDB
MMP3
Tchem
Novelty:  0.00041675
Score:  0.917
Data Source:  Reactome,STRINGDB
MMP10
Tchem
Novelty:  0.00112113
Score:  0.9
Data Source:  STRINGDB
TCN1
Tbio
Novelty:  0.00305315
Score:  0.9
Data Source:  STRINGDB
CPB1
Tchem
Family:  Enzyme
Novelty:  0.00108031
Score:  0.829
Data Source:  STRINGDB
CEL
Tchem
Family:  Enzyme
Novelty:  0.00156761
Score:  0.761
Data Source:  STRINGDB
TAT
Tbio
Family:  Enzyme
Novelty:  0.00079176
Score:  0.753
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Cobalamin (Cbl, vitamin B12) transport and metabolism
Degradation of the extracellular matrix
Extracellular matrix organization
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
5
3
1.2
96.1
3
3
1
1.3
84
lymphocyte count
2
2
2
77.8
1
1
0
1.1
73.3
1
1
1
63.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.2
96.1
1
1.3
84
lymphocyte count
2
77.8
0
1.1
73.3
1
63.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chymotrypsinogen B2
VGNC:13690
736783
Macaque
chymotrypsinogen B2
711100
Mouse
MGI:88559
66473
Rat
RGD:2444
24291
Pig
chymotrypsinogen B2
100621642
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chymotrypsinogen B2
Macaque
chymotrypsinogen B2
Mouse
Rat
Pig
chymotrypsinogen B2
Publication Statistics
PubMed Score 59.01
PubMed score by year
PubTator Score 27.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title