Protein Summary
This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This gene is located adjacent to a related chymotrypsinogen gene. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2016]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 72.01 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 186 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 72.01 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 186 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 41
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (41)
Protein-Protein Interactions (46)
PNMA2
Novelty: 0.00162709
p_int: 0.953386062
p_ni: 0.046613937
p_wrong: 1e-9
Score: 0.323
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (7)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (35)
Items per page:
1 – 5 of 35
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
type 2 diabetes mellitus | 6 | 5 | 3 | 1.2 | 98.6 | ||||
type 1 diabetes mellitus | 3 | 3 | 1 | 1.3 | 94.7 | ||||
blood protein measurement | 4 | 4 | 5 | 90.1 | |||||
1 | 1 | 0 | 1.1 | 84 | |||||
2 | 1 | 0 | 1.4 | 74.3 | |||||
Items per page:
1 – 5 of 35
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
type 2 diabetes mellitus | 3 | 1.2 | 98.6 | ||||
type 1 diabetes mellitus | 1 | 1.3 | 94.7 | ||||
blood protein measurement | 5 | 90.1 | |||||
0 | 1.1 | 84 | |||||
0 | 1.4 | 74.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | chymotrypsinogen B2 | VGNC:13690 | 736783 | |||||
Macaque | chymotrypsinogen B2 | 711100 | ||||||
Mouse | MGI:88559 | 66473 | ||||||
Rat | RGD:2444 | 24291 | ||||||
Pig | chymotrypsinogen B2 | 100621642 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | chymotrypsinogen B2 | |||||
Macaque | chymotrypsinogen B2 | |||||
Mouse | ||||||
Rat | ||||||
Pig | chymotrypsinogen B2 | |||||
Publication Statistics
PubMed Score 72.01
PubMed score by year
PubTator Score 27.46
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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