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Tbio
JUND
Transcription factor jun-D

Protein Summary
Description
Transcription factor binding AP-1 sites. The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252818
  • ENSP00000252818
  • ENSG00000130522

Symbol
  • AP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
molecular function
0.93
hub protein
0.92
biological process
0.9
disease perturbation
0.9


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GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287.61   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 600   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287.61   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
1
1
1
24.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
grip strength measurement
1
24.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96648
16478
Rat
RGD:2945
24518
Dog
JunD proto-oncogene, AP-1 transcription factor subunit
VGNC:42199
609409
Opossum
JunD proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6206]
Xenopus
jun D proto-oncogene
XB-GENE-955776
100126216
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
JunD proto-oncogene, AP-1 transcription factor subunit
Opossum
JunD proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6206]
Xenopus
jun D proto-oncogene
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (26)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent gene expression
Signal Transduction
Signaling by Nuclear Receptors
Gene Ontology Terms (36)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (152)
1 – 10 of 152
FOSL2
Tbio
Family: TF
Novelty: 0.00375452
p_int: 0.99999998
p_ni: 2e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
FOS
Tbio
Family: TF
Novelty: 0.00006103
p_int: 0.999999156
p_ni: 8.44e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
BATF3
Tbio
Family: TF
Novelty: 0.01554987
p_int: 0.999997697
p_ni: 0.00000217
p_wrong: 1.33e-7
Score: 0.898
Data Source: BioPlex,STRINGDB
ARIH1
Tbio
Family: Enzyme
Novelty: 0.0258739
p_int: 0.999985779
p_ni: 0.00001422
p_wrong: 1e-9
Score: 0.442
Data Source: BioPlex,STRINGDB
JUNB
Tbio
Family: TF
Novelty: 0.00841656
p_int: 0.999969824
p_ni: 0.00002388
p_wrong: 0.000006295
Score: 0.984
Data Source: BioPlex,STRINGDB
ATF2
Tbio
Family: TF
Novelty: 0.00457832
p_int: 0.999956794
p_ni: 0.00003515
p_wrong: 0.000008056
Score: 0.992
Data Source: BioPlex,STRINGDB
RALBP1
Tbio
Novelty: 0.01525176
p_int: 0.999858373
p_ni: 0.000141608
p_wrong: 1.9e-8
Data Source: BioPlex
CEBPG
Tbio
Family: TF
Novelty: 0.07956633
p_int: 0.99963323
p_ni: 0.000250371
p_wrong: 0.000116398
Score: 0.348
Data Source: BioPlex,STRINGDB
MLLT6
Tdark
Family: Epigenetic
Novelty: 0.03728427
p_int: 0.996851054
p_ni: 0.00087013
p_wrong: 0.002278816
Score: 0.671
Data Source: BioPlex,STRINGDB
CREB5
Tbio
Family: TF
Novelty: 0.03857106
p_int: 0.991435867
p_ni: 0.000189723
p_wrong: 0.00837441
Score: 0.916
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  287.61

PubMed score by year
PubTator Score  360.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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