Tbio JUND Transcription factor jun-D

Protein Summary

Description

Transcription factor binding AP-1 sites. The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

Uniprot Accession IDs

• P17535
• Q53EK9

Gene Name

• JUND

Ensembl ID

• ENST00000252818
• ENSP00000252818
• ENSG00000130522

Symbol

• AP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.95
molecular function	0.93
hub protein	0.92
biological process	0.9
disease perturbation	0.9

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Transcription Factor Jun-d

Protein / Nucleic Acid Binding / Transcription Factor Jun-d

DTO Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Transcription Factor Jun-d

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.68   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 600   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.68   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 600   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0