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Tchem
AKR1C4
Aldo-keto reductase family 1 member C4

Protein Summary
Description
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263126
  • ENSP00000263126
  • ENSG00000198610
  • ENST00000380448
  • ENSP00000369814

Symbol
  • CHDR
  • C11
  • CDR
  • DD4
  • CHDR
  • DD-4
  • HAKRA
  • 3-alpha-HSD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
molecular function
0.91
cell type or tissue
0.77
chemical
0.75
biological process
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.39   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.39   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
4
4
92.8
sex hormone-binding globulin measurement
6
2
6
89.9
alkaline phosphatase measurement
2
2
1
7.2
85.8
triglyceride measurement
6
5
6
84.7
blood metabolite measurement
1
1
1
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
4
92.8
sex hormone-binding globulin measurement
6
89.9
alkaline phosphatase measurement
1
7.2
85.8
triglyceride measurement
6
84.7
blood metabolite measurement
1
82
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 1 member C4
VGNC:53394
450274
Macaque
aldo-keto reductase family 1, member C2
711360
Mouse
MGI:2151104
116852
Rat
RGD:1306847
307092
Opossum
aldo-keto reductase family 1 member C1 homolog
100022478
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 1 member C4
Macaque
aldo-keto reductase family 1, member C2
Mouse
Rat
Opossum
aldo-keto reductase family 1 member C1 homolog
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P17516-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
G alpha (i) signalling events
GPCR downstream signalling
Metabolism
Metabolism of fat-soluble vitamins
Gene Ontology Terms (25)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (44)
1 – 10 of 44
AKR1C3
Tchem
Family:  Enzyme
Novelty:  0.00257785
p_int:  1
Score:  0.936
Data Source:  BioPlex,STRINGDB
AKR1C2
Tchem
Family:  Enzyme
Novelty:  0.00134228
p_int:  0.999999875
p_ni:  1.25e-7
Score:  0.867
Data Source:  BioPlex,STRINGDB
PLXDC2
Tbio
Novelty:  0.06496695
p_int:  0.999655887
p_ni:  0.000344113
Score:  0.241
Data Source:  BioPlex,STRINGDB
SRD5A1
Tclin
Family:  Enzyme
Novelty:  0.00987219
Score:  0.953
Data Source:  STRINGDB
HSD11B1
Tclin
Family:  Enzyme
Novelty:  0.00105097
Score:  0.944
Data Source:  STRINGDB
SRD5A2
Tclin
Family:  Enzyme
Novelty:  0.00281044
Score:  0.944
Data Source:  STRINGDB
SRD5A3
Tbio
Family:  Enzyme
Novelty:  0.02896703
Score:  0.925
Data Source:  STRINGDB
DHDH
Tbio
Family:  Enzyme
Novelty:  0.00284827
Score:  0.924
Data Source:  STRINGDB
CYP27A1
Tchem
Family:  Enzyme
Novelty:  0.00071796
Score:  0.914
Data Source:  STRINGDB
AKR1D1
Tbio
Family:  Enzyme
Novelty:  0.01264297
Score:  0.906
Data Source:  STRINGDB
Publication Statistics
PubMed Score  106.39

PubMed score by year
PubTator Score  313.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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