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Tbio
HOXB6
Homeobox protein Hox-B6

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225648
  • ENSP00000225648
  • ENSG00000108511
  • ENST00000484302
  • ENSP00000420009

Symbol
  • HOX2B
  • HOX2
  • HU-2
  • HOX2B
  • Hox-2.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
gene perturbation
0.96
protein domain
0.85
disease perturbation
0.74
virus perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.15   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.15   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
3
3
73.8
hemoglobin measurement
1
1
1
61.4
1
1
0
1.1
60.5
apolipoprotein B measurement
1
1
1
59
grip strength measurement
1
1
1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
73.8
hemoglobin measurement
1
61.4
0
1.1
60.5
apolipoprotein B measurement
1
59
grip strength measurement
1
53.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox B6
VGNC:51663
749195
Mouse
MGI:96187
15414
Rat
RGD:1562142
497986
Dog
homeobox B6
VGNC:41752
491056
Horse
homeobox B6
VGNC:18845
100055701
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox B6
Mouse
Rat
Dog
homeobox B6
Horse
homeobox B6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P17509-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (78)
1 – 10 of 78
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.999999996
p_ni:  3e-9
p_wrong:  1e-9
Data Source:  BioPlex
DCAF17
Tbio
Novelty:  0.04261326
p_int:  0.999999225
p_ni:  7.72e-7
p_wrong:  3e-9
Data Source:  BioPlex
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
p_int:  0.999997302
p_ni:  4.14e-7
p_wrong:  0.000002284
Score:  0.189
Data Source:  BioPlex,STRINGDB
KCTD9
Tbio
Novelty:  0.22841768
p_int:  0.999815986
p_ni:  0.000184013
Data Source:  BioPlex
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.999684127
p_ni:  0.000315873
Data Source:  BioPlex
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.999479006
p_ni:  0.000003274
p_wrong:  0.00051772
Score:  0.2
Data Source:  BioPlex,STRINGDB
TRAPPC6B
Tbio
Novelty:  0.15086531
p_int:  0.996463092
p_ni:  0.003536902
p_wrong:  6e-9
Data Source:  BioPlex
C7orf43
Tdark
Novelty:  1.11975505
p_int:  0.996237305
p_ni:  0.003762693
p_wrong:  2e-9
Data Source:  BioPlex
C4A
Tbio
Novelty:  0.00062793
p_int:  0.994462905
p_ni:  0.005341136
p_wrong:  0.00019596
Data Source:  BioPlex
TRAPPC9
Tbio
Novelty:  0.02703008
p_int:  0.986702714
p_ni:  0.013297286
Data Source:  BioPlex
Publication Statistics
PubMed Score  55.15

PubMed score by year
PubTator Score  30.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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