You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HOXB4
Homeobox protein Hox-B4

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332503
  • ENSP00000328928
  • ENSG00000182742

Symbol
  • HOX2F
  • HOX2
  • HOX2F
  • HOX-2.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.82
phenotype
0.72
PubMedID
0.68
transcription factor binding site profile
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.55   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.55   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.999844079
p_ni:  3e-9
p_wrong:  0.000155918
Data Source:  BioPlex
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
Score:  0.976
Data Source:  STRINGDB
HOXB6
Tbio
Family:  TF
Novelty:  0.0176813
Score:  0.975
Data Source:  STRINGDB
HOXA5
Tbio
Family:  TF
Novelty:  0.0058504
Score:  0.972
Data Source:  STRINGDB
HOXB7
Tbio
Family:  TF
Novelty:  0.00765378
Score:  0.97
Data Source:  STRINGDB
HOXC5
Tbio
Family:  TF
Novelty:  0.05354226
Score:  0.969
Data Source:  STRINGDB
HOXA7
Tbio
Family:  TF
Novelty:  0.00337527
Score:  0.968
Data Source:  STRINGDB
HOXC4
Tbio
Family:  TF
Novelty:  0.02206351
Score:  0.967
Data Source:  STRINGDB
HOXC6
Tbio
Family:  TF
Novelty:  0.00991192
Score:  0.967
Data Source:  STRINGDB
HOXA6
Tbio
Family:  TF
Novelty:  0.04558872
Score:  0.967
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
65.7
hemoglobin measurement
1
1
1
61.4
grip strength measurement
1
1
1
53.3
1
1
1
46.5
comparative body size at age 10, self-reported
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
65.7
hemoglobin measurement
1
61.4
grip strength measurement
1
53.3
1
46.5
comparative body size at age 10, self-reported
1
45.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox B4
VGNC:9326
749218
Mouse
MGI:96185
15412
Rat
RGD:1560113
497988
Dog
homeobox B4 [Source:HGNC Symbol;Acc:HGNC:5115]
Cow
homeobox B4
VGNC:29920
768240
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox B4
Mouse
Rat
Dog
homeobox B4 [Source:HGNC Symbol;Acc:HGNC:5115]
Cow
homeobox B4
Publication Statistics
PubMed Score 181.55
PubMed score by year
PubTator Score 108.10
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title