Tbio UBTF Nucleolar transcription factor 1

Protein Summary

Description

Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• P17480
• A8K6R8

Gene Name

• UBTF

Ensembl ID

• ENST00000302904
• ENSP00000302640
• ENSG00000108312
• ENST00000343638
• ENSP00000345297
• ENST00000393606
• ENSP00000377231
• ENST00000436088
• ENSP00000390669
• ENST00000526094
• ENSP00000432925
• ENST00000529383
• ENSP00000435708
• ENST00000533177
• ENSP00000437180

Symbol

• UBF
• UBF1
• UBF
• UBF1
• UBF2
• UBF-1
• CONDBA
• NOR-90

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.98
disease perturbation	0.93
protein complex	0.89
hub protein	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.98   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 371   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.98   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0