You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GJA1
Gap junction alpha-1 protein

Protein Summary
Description
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of lo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282561
  • ENSP00000282561
  • ENSG00000152661
  • ENST00000647564
  • ENSP00000497565
  • ENST00000649003
  • ENSP00000497283
  • ENST00000649132
  • ENSP00000497788
  • ENST00000650427
  • ENSP00000497367

Symbol
  • GJAL
  • HSS
  • CMDR
  • CX43
  • EKVP
  • GJAL
  • ODDD
  • AVSD3
  • EKVP3
  • HLHS1
  • PPKCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
PubMedID
1
chemical
0.99
small molecule perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4493.53   (req: < 5)
Gene RIFs: 476   (req: <= 3)
Antibodies: 1119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4493.53   (req: >= 5)
Gene RIFs: 476   (req: > 3)
Antibodies: 1119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (29)
Formation of annular gap junctions (R-HSA-196025)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of annular gap junctions
Reactome
Gap junction assembly
Reactome
Gap junction degradation
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Name
Explore in Pharos
Explore in Source
Formation of annular gap junctions
Gap junction assembly
Gap junction degradation
Gap junction trafficking
Gap junction trafficking and regulation
Gene Ontology Terms (31)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Protein-Protein Interactions (312)
1 – 10 of 312
NKAIN1
Tdark
Family: Enzyme
Novelty: 0.60115607
p_int: 0.999557387
p_ni: 0.000442613
Data Source: BioPlex
MICB
Tbio
Novelty: 0.00776922
p_int: 0.998417022
p_ni: 0.001582978
Data Source: BioPlex
DPEP1
Tclin
Family: Enzyme
Novelty: 0.0033193
p_int: 0.998196701
p_ni: 0.001803299
Data Source: BioPlex
ADGRG5
Tdark
Family: GPCR
Novelty: 0.38877844
p_int: 0.997315941
p_ni: 0.002684059
Data Source: BioPlex
SLC39A12
Tbio
Family: Transporter
Novelty: 0.11255353
p_int: 0.993642182
p_ni: 0.006357818
Data Source: BioPlex
UPK1A
Tbio
Novelty: 0.02382993
p_int: 0.980045199
p_ni: 0.019954801
Data Source: BioPlex
ZACN
Tchem
Family: IC
Novelty: 0.53571429
p_int: 0.966881735
p_ni: 0.033118265
Data Source: BioPlex
HTR3A
Tclin
Family: IC
Novelty: 0.00035394
p_int: 0.963965824
p_ni: 0.036034176
Score: 0.159
Data Source: BioPlex,STRINGDB
SLC39A4
Tbio
Family: Transporter
Novelty: 0.00826526
p_int: 0.962773393
p_ni: 0.037226607
Data Source: BioPlex
TSPAN31
Tdark
Novelty: 0.19615058
p_int: 0.957213032
p_ni: 0.042786968
Data Source: BioPlex
Publication Statistics
PubMed Score  4493.53

PubMed score by year
PubTator Score  2310.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: