Tbio ITGA2 Integrin alpha-2

Protein Summary

Description

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• P17301
• Q14595

Gene Name

• ITGA2

Ensembl ID

• ENST00000296585
• ENSP00000296585
• ENSG00000164171

Symbol

• CD49B
• BR
• GPIa
• CD49B
• HPA-5
• VLA-2
• VLAA2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
biological term	0.99
gene perturbation	0.95
molecular function	0.86
protein domain	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.95   (req: < 5)

Gene RIFs: 232   (req: <= 3)

Antibodies: 1284   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.95   (req: >= 5)

Gene RIFs: 232   (req: > 3)

Antibodies: 1284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (236)

Explore Interacting Targets

1 – 10 of 236

• See Interactions on String-DB

LGALS8

Tchem

Novelty:  0.00623836

p_int:  0.999999167

p_ni:  8.32e-7

Data Source:  BioPlex

BTNL8

Tdark

Novelty:  0.40339869

p_int:  0.999993751

p_ni:  0.000006249

Data Source:  BioPlex

MGAT4C

Tdark

Family:  Enzyme

Novelty:  0.19680806

p_int:  0.997838237

p_ni:  0.00216161

p_wrong:  1.53e-7

Data Source:  BioPlex

EDDM3B

Tdark

Novelty:  0.12874735

p_int:  0.996628845

p_ni:  0.003298579

p_wrong:  0.000072576

Data Source:  BioPlex

LGALS3

Tchem

Novelty:  0.00032754

p_int:  0.994410203

p_ni:  0.005582239

p_wrong:  0.000007558

Score:  0.259

Data Source:  BioPlex,STRINGDB

TMED6

Tdark

Novelty:  0.598611

p_int:  0.992596317

p_ni:  0.007268902

p_wrong:  0.000134782

Data Source:  BioPlex

SCGB1D1

Tbio

Novelty:  0.04199997

p_int:  0.989638536

p_ni:  0.01030757

p_wrong:  0.000053895

Data Source:  BioPlex

ADAM18

Tdark

Family:  Enzyme

Novelty:  0.22622379

p_int:  0.96693406

p_ni:  0.033044539

p_wrong:  0.0000214

Data Source:  BioPlex

CD160

Tbio

Novelty:  0.01511748

p_int:  0.959889276

p_ni:  0.040103897

p_wrong:  0.000006827

Data Source:  BioPlex

SERPINA12

Tbio

Novelty:  0.00549132

p_int:  0.959160053

p_ni:  0.036830624

p_wrong:  0.004009323

Data Source:  BioPlex

Nearest Tclin Targets (13)

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Upstream (5)

Downstream (8)

1 – 5 of 5

ITGB1

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  13

1: PI3K-Akt signaling pathway

2: Platelet activation

3: ECM-receptor interaction

4: Focal adhesion

more:  9 more common pathways

ITGB3

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  12

1: PI3K-Akt signaling pathway

2: Platelet activation

3: ECM-receptor interaction

4: Focal adhesion

more:  8 more common pathways

ITGB7

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  8

1: PI3K-Akt signaling pathway

2: ECM-receptor interaction

3: Focal adhesion

4: Dilated cardiomyopathy (DCM)

more:  4 more common pathways

ITGA2B

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  12

1: PI3K-Akt signaling pathway

2: Platelet activation

3: ECM-receptor interaction

4: Focal adhesion

more:  8 more common pathways

ITGA4

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  9

1: PI3K-Akt signaling pathway

2: ECM-receptor interaction

3: Focal adhesion

4: Dilated cardiomyopathy (DCM)

more:  5 more common pathways

Pathways (259)

Reactome (17)

KEGG (14)

PathwayCommons (8)

WikiPathways (220)

Axon guidance (R-HSA-422475)

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5

1 – 5 of 17

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	CHL1 interactions	9 targets	R-HSA-447041
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	ECM proteoglycans	56 targets	R-HSA-3000178
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
CHL1 interactions	9 targets	R-HSA-447041
Developmental Biology	1055 targets	R-HSA-1266738
ECM proteoglycans	56 targets	R-HSA-3000178
Extracellular matrix organization	297 targets	R-HSA-1474244

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (65)

Functions (11)

Components (10)

Processes (44)

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10

1 – 10 of 11

GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Physical Interaction (IPI)	UniProtKB
collagen binding	Inferred from Mutant Phenotype (IMP)	UniProtKB
collagen binding involved in cell-matrix adhesion	Inferred from Mutant Phenotype (IMP)	UniProtKB
collagen receptor activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
amyloid-beta binding	Inferred from Sequence or structural Similarity (ISS)	ARUK-UCL
heparan sulfate proteoglycan binding	Traceable Author Statement (TAS)	ARUK-UCL
integrin binding	Inferred from Electronic Annotation (IEA)	Ensembl
laminin binding	Inferred from Electronic Annotation (IEA)	Ensembl
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (16)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	3	1	2	5.5	87
FEV/FEC ratio	EFO_0004713	1	1	1		82.8
heel bone mineral density	EFO_0009270	2	1	2		68
serum alanine aminotransferase measurement	EFO_0004735	2	1	1	7.3	61.4
peak expiratory flow	EFO_0009718	1	1	1		60.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	2	5.5	87
FEV/FEC ratio	EFO_0004713	1		82.8
heel bone mineral density	EFO_0009270	2		68
serum alanine aminotransferase measurement	EFO_0004735	1	7.3	61.4
peak expiratory flow	EFO_0009718	1		60.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Calcium
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Integrin

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
chronic obstructive pulmonary disease
FEV/FEC ratio
forced expiratory volume
heel bone mineral density
hematocrit
hemoglobin measurement
low density lipoprotein cholesterol measurement
mean platelet volume
myocardial infarction

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
integument phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha 2	VGNC:4054	471550
Macaque	integrin subunit alpha 2		703572
Mouse	integrin alpha 2	MGI:96600	16398
Rat	integrin subunit alpha 2	RGD:621632	170921
Dog	integrin subunit alpha 2	VGNC:42123	489208

Species	Name	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha 2
Macaque	integrin subunit alpha 2
Mouse	integrin alpha 2
Rat	integrin subunit alpha 2
Dog	integrin subunit alpha 2

Publication Statistics

PubMed Score 637.95

PubMed score by year

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PubTator Score 312.50

PubTator score by year

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Related Publications

Text Mined References (385)

GeneRif Annotations (232)

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PMID	Year	Title