Protein Summary
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmu ...more
- ENST00000296585
- ENSP00000296585
- ENSG00000164171
- CD49B
- BR
- GPIa
- CD49B
- HPA-5
- VLA-2
- VLAA2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.99 | ||
biological term | 0.99 | ||
gene perturbation | 0.95 | ||
molecular function | 0.86 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 637.95 (req: < 5)
Gene RIFs: 232 (req: <= 3)
Antibodies: 1284 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 637.95 (req: >= 5)
Gene RIFs: 232 (req: > 3)
Antibodies: 1284 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 55
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (236)
MGAT4C
Family: Enzyme
Novelty: 0.19680806
p_int: 0.997838237
p_ni: 0.00216161
p_wrong: 1.53e-7
Data Source: BioPlex
EDDM3B
Novelty: 0.12874735
p_int: 0.996628845
p_ni: 0.003298579
p_wrong: 0.000072576
Data Source: BioPlex
LGALS3
Novelty: 0.00032754
p_int: 0.994410203
p_ni: 0.005582239
p_wrong: 0.000007558
Score: 0.259
Data Source: BioPlex,STRINGDB
TMED6
Novelty: 0.598611
p_int: 0.992596317
p_ni: 0.007268902
p_wrong: 0.000134782
Data Source: BioPlex
SCGB1D1
Novelty: 0.04199997
p_int: 0.989638536
p_ni: 0.01030757
p_wrong: 0.000053895
Data Source: BioPlex
ADAM18
Family: Enzyme
Novelty: 0.22622379
p_int: 0.96693406
p_ni: 0.033044539
p_wrong: 0.0000214
Data Source: BioPlex
CD160
Novelty: 0.01511748
p_int: 0.959889276
p_ni: 0.040103897
p_wrong: 0.000006827
Data Source: BioPlex
SERPINA12
Novelty: 0.00549132
p_int: 0.959160053
p_ni: 0.036830624
p_wrong: 0.004009323
Data Source: BioPlex
Nearest Tclin Targets (13)
Upstream (5)
Downstream (8)
1 – 5 of 5
Pathways (259)
Reactome (17)
KEGG (14)
PathwayCommons (8)
WikiPathways (220)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | CHL1 interactions | ||||
Reactome | Developmental Biology | ||||
Reactome | ECM proteoglycans | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
CHL1 interactions | ||||
Developmental Biology | ||||
ECM proteoglycans | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (65)
Functions (11)
Components (10)
Processes (44)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
Traceable Author Statement (TAS) | ARUK-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 3 | 1 | 2 | 5.5 | 87 | ||||
FEV/FEC ratio | 1 | 1 | 1 | 82.8 | |||||
heel bone mineral density | 2 | 1 | 2 | 68 | |||||
serum alanine aminotransferase measurement | 2 | 1 | 1 | 7.3 | 61.4 | ||||
peak expiratory flow | 1 | 1 | 1 | 60.5 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 2 | 5.5 | 87 | ||||
FEV/FEC ratio | 1 | 82.8 | |||||
heel bone mineral density | 2 | 68 | |||||
serum alanine aminotransferase measurement | 1 | 7.3 | 61.4 | ||||
peak expiratory flow | 1 | 60.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | integrin subunit alpha 2 | VGNC:4054 | 471550 | |||||
Macaque | integrin subunit alpha 2 | 703572 | ||||||
Mouse | MGI:96600 | 16398 | ||||||
Rat | RGD:621632 | 170921 | ||||||
Dog | integrin subunit alpha 2 | VGNC:42123 | 489208 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | integrin subunit alpha 2 | |||||
Macaque | integrin subunit alpha 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | integrin subunit alpha 2 | |||||
Publication Statistics
PubMed Score 637.95
PubMed score by year
PubTator Score 312.50
PubTator score by year
Related Publications
Text Mined References (385)
GeneRif Annotations (232)
Items per page:
0 of 0
PMID | Year | Title |
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