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Tchem
PRKCA
Protein kinase C alpha type

Protein Summary
Description
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000413366
  • ENSP00000408695
  • ENSG00000154229

Symbol
  • PKCA
  • PRKACA
  • AAG6
  • PKCA
  • PRKACA
  • PKCI+/-
  • PKCalpha
  • PKC-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
pathway
1
protein domain
1


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1767.18   (req: < 5)
Gene RIFs: 435   (req: <= 3)
Antibodies: 1093   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1767.18   (req: >= 5)
Gene RIFs: 435   (req: > 3)
Antibodies: 1093   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 353
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2