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Tchem
PRKCA
Protein kinase C alpha type

Protein Classes
Protein Summary
Description
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000413366
  • ENSP00000408695
  • ENSG00000154229

Symbol
  • PKCA
  • PRKACA
  • AAG6
  • PKCA
  • PRKACA
  • PKCI+/-
  • PKCalpha
  • PKC-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
pathway
1
protein domain
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1650.55   (req: < 5)
Gene RIFs: 435   (req: <= 3)
Antibodies: 1093   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1650.55   (req: >= 5)
Gene RIFs: 435   (req: > 3)
Antibodies: 1093   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 332
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
2
2
3
87.9
QRS amplitude
1
1
0
32
68.5
QRS complex
1
1
0
32
68.5
electrocardiography
1
1
12
62.6
mathematical ability
2
1
2
62.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
3
87.9
QRS amplitude
0
32
68.5
QRS complex
0
32
68.5
electrocardiography
12
62.6
mathematical ability
2
62.2
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (258)
Acetylcholine regulates insulin secretion (R-HSA-399997)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 66
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine regulates insulin secretion
Reactome
Axon guidance
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca-dependent events
Reactome
Ca2+ pathway
Name
Explore in Pharos
Explore in Source
Acetylcholine regulates insulin secretion
Axon guidance
Beta-catenin independent WNT signaling
Ca-dependent events
Ca2+ pathway
Gene Ontology Terms (51)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (424)
1 – 10 of 424
PRKCB
Tchem
Family: Kinase
Novelty: 0.00189802
p_int: 1
Score: 0.937
Data Source: BioPlex,STRINGDB
PRKCG
Tchem
Family: Kinase
Novelty: 0.00291817
p_int: 0.999999999
Score: 0.937
Data Source: BioPlex,STRINGDB
PRKCH
Tchem
Family: Kinase
Novelty: 0.01311926
p_int: 0.999975418
p_wrong: 0.000024582
Score: 0.939
Data Source: BioPlex,STRINGDB
PIP5K1A
Tbio
Family: Kinase
Novelty: 0.05039085
p_int: 0.99995138
p_ni: 0.00004862
Score: 0.151
Data Source: BioPlex,STRINGDB
SHCBP1
Tbio
Novelty: 0.09160318
p_int: 0.999910888
p_ni: 0.000089112
Score: 0.179
Data Source: BioPlex,STRINGDB
GCLM
Tbio
Family: Enzyme
Novelty: 0.00395815
p_int: 0.99969649
p_ni: 0.000303016
p_wrong: 4.94e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
STARD7
Tbio
Novelty: 0.04511594
p_int: 0.99803782
p_ni: 0.001962058
p_wrong: 1.22e-7
Score: 0.18
Data Source: BioPlex,STRINGDB
CYP2S1
Tbio
Novelty: 0.02967417
p_int: 0.998020611
p_ni: 0.001979389
Data Source: BioPlex
SLC25A41
Tdark
Family: Transporter
Novelty: 1.04918395
p_int: 0.994292869
p_ni: 0.005707131
Data Source: BioPlex
FGD4
Tbio
Novelty: 0.01920119
p_int: 0.937756172
p_ni: 3.76e-7
p_wrong: 0.062243451
Score: 0.351
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1650.55

PubMed score by year
PubTator Score  1710.48

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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