Tbio BPI Bactericidal permeability-increasing protein

Protein Summary

Description

The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• P17213
• B2RCY2
• Q1ZZU8
• Q5JRW0
• Q8IW58
• Q9BYZ9
• Q9H1L2
• Q9H1M8
• Q9H203
• Q9UCT4
• Q9UD65
• BPI

Gene Name

• BPI

Ensembl ID

• ENST00000262865
• ENSP00000262865
• ENSG00000101425

Symbol

• rBPI
• BPIFD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.84
protein domain	0.73
tissue sample	0.59
biological term	0.57
cellular component	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.84   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 311   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.84   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0