Pharos : Target Details

Tclin

Protein Classes

Protein Summary

Description

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded pro ...more

Uniprot Accession IDs

Gene Name

IFNAR1

Ensembl ID

ENST00000270139
ENSP00000270139
ENSG00000142166

Symbol

IFNAR
AVP
IFRC
IFNAR
IFNBR
IFN-alpha-REC

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93

hub protein	0.85

transcription factor perturbation	0.84

cell type or tissue	0.82

transcription factor binding site profile	0.82

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 710.56 (req: < 5)

View Publications

Gene RIFs: 99 (req: <= 3)

View Gene RIFs

Antibodies: 728 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 710.56 (req: >= 5)

Gene RIFs: 99 (req: > 3)

Antibodies: 728 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6

Explore Approved Drugs

Approved Drugs (6)

1 – 6 of 6

peginterferon beta-1a

interferon beta-1a

interferon beta-1b

peginterferon alfa-2a

peginterferon alfa-2b

ropeginterferon alfa-2b

GWAS Traits (1)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
rheumatoid arthritis	EFO_0000685	1	1	0	1.1	2.9

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
rheumatoid arthritis	EFO_0000685	0	1.1	2.9

Beta Count

Odds Ratio

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID
Chimp	interferon alpha and beta receptor subunit 1	VGNC:7183	458516

Macaque	interferon alpha and beta receptor subunit 1		699604

Mouse	interferon (alpha and beta) receptor 1	MGI:107658	15975

Rat	interferon alpha and beta receptor subunit 1	RGD:1305399	288264

Dog	interferon alpha/beta receptor 1		609830

Species	Name	OMA	EggNOG	Inparanoid
Chimp	interferon alpha and beta receptor subunit 1

Macaque	interferon alpha and beta receptor subunit 1

Mouse	interferon (alpha and beta) receptor 1

Rat	interferon alpha and beta receptor subunit 1

Dog	interferon alpha/beta receptor 1

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (245)

Reactome (5)

KEGG (17)

PathwayCommons (9)

WikiPathways (214)

Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Reactome	Immune System	2246 targets	R-HSA-168256

Reactome	Interferon Signaling	280 targets	R-HSA-913531

Reactome	Interferon alpha/beta signaling	136 targets	R-HSA-909733

Reactome	Regulation of IFNA signaling	25 targets	R-HSA-912694

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Immune System	2246 targets	R-HSA-168256

Interferon Signaling	280 targets	R-HSA-913531

Interferon alpha/beta signaling	136 targets	R-HSA-909733

Regulation of IFNA signaling	25 targets	R-HSA-912694

Gene Ontology Terms (12)

Functions (2)

Components (4)

Processes (6)

Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
type I interferon receptor activity	Inferred from Direct Assay (IDA)	UniProtKB

type I interferon binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Protein-Protein Interactions (208)

1 – 10 of 208

See Interactions on String-DB

IFNB1

Tbio

Novelty: 0.00011797

p_int: 0.999940554

p_ni: 0.000059445

p_wrong: 1e-9

Score: 0.996

Data Source: BioPlex,Reactome,STRINGDB

BTRC

Tbio

Novelty: 0.00293475

p_int: 0.999866272

p_ni: 0.000133727

p_wrong: 1e-9

Score: 0.456

Data Source: BioPlex,STRINGDB

TNFRSF10A

Tchem

Novelty: 0.0003383

p_int: 0.999623925

p_ni: 0.000376073

p_wrong: 2e-9

Score: 0.244

Data Source: BioPlex,STRINGDB

CTLA4

Tclin

Novelty: 0.00012781

p_int: 0.999162067

p_ni: 0.000586131

p_wrong: 0.000251801

Score: 0.398

Data Source: BioPlex,STRINGDB

TYK2

Tclin

Family: Kinase

Novelty: 0.00237955

Score: 0.998

Data Source: Reactome,STRINGDB

IFNAR2

Tclin

Novelty: 0.00453303

Score: 0.998

Data Source: Reactome,STRINGDB

IFNA2

Tbio

Novelty: 0.00032935

Score: 0.994

Data Source: STRINGDB

CCNE1

Tchem

Novelty: 0.00237201

Score: 0.993

Data Source: STRINGDB

CDK2

Tchem

Family: Kinase

Novelty: 0.00032118

Score: 0.993

Data Source: STRINGDB

CDK4

Tclin

Family: Kinase

Novelty: 0.00036742

Score: 0.993

Data Source: STRINGDB

Publication Statistics

PubMed Score 710.56

PubMed score by year

PubTator Score 237.53

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword


3D-structure

Alternative splicing

Cell membrane

Complete proteome

Disulfide bond

Endosome

Glycoprotein

Isopeptide bond

Lipoprotein

Lysosome

GWAS Trait


rheumatoid arthritis

MGI Phenotype


cardiovascular system phenotype

hematopoietic system phenotype

homeostasis/metabolism phenotype

immune system phenotype

mortality/aging

neoplasm

skeleton phenotype

vision/eye phenotype