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Tclin
IFNAR1
Interferon alpha/beta receptor 1

Protein Summary
Description
Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270139
  • ENSP00000270139
  • ENSG00000142166

Symbol
  • IFNAR
  • AVP
  • IFRC
  • IFNAR
  • IFNBR
  • IFN-alpha-REC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
hub protein
0.85
transcription factor perturbation
0.84
cell type or tissue
0.82
transcription factor binding site profile
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 710.56   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 728   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 710.56   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 728   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
2.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon alpha and beta receptor subunit 1
VGNC:7183
458516
Macaque
interferon alpha and beta receptor subunit 1
699604
Mouse
MGI:107658
15975
Rat
RGD:1305399
288264
Dog
interferon alpha/beta receptor 1
609830
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon alpha and beta receptor subunit 1
Macaque
interferon alpha and beta receptor subunit 1
Mouse
Rat
Dog
interferon alpha/beta receptor 1
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (245)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Reactome
Regulation of IFNA signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Regulation of IFNA signaling
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (208)
1 – 10 of 208
IFNB1
Tbio
Novelty: 0.00011797
p_int: 0.999940554
p_ni: 0.000059445
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999866272
p_ni: 0.000133727
p_wrong: 1e-9
Score: 0.456
Data Source: BioPlex,STRINGDB
TNFRSF10A
Tchem
Novelty: 0.0003383
p_int: 0.999623925
p_ni: 0.000376073
p_wrong: 2e-9
Score: 0.244
Data Source: BioPlex,STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.999162067
p_ni: 0.000586131
p_wrong: 0.000251801
Score: 0.398
Data Source: BioPlex,STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
Score: 0.998
Data Source: Reactome,STRINGDB
IFNAR2
Tclin
Novelty: 0.00453303
Score: 0.998
Data Source: Reactome,STRINGDB
IFNA2
Tbio
Novelty: 0.00032935
Score: 0.994
Data Source: STRINGDB
CCNE1
Tchem
Novelty: 0.00237201
Score: 0.993
Data Source: STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
Score: 0.993
Data Source: STRINGDB
CDK4
Tclin
Family: Kinase
Novelty: 0.00036742
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  710.56

PubMed score by year
PubTator Score  237.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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