Tclin IFNAR1 Interferon alpha/beta receptor 1

Protein Summary

Description

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P17181
• B2R6L9
• B4DNT3
• D3DSF0
• Q53GW9
• Q53H11
• Q6PKD7
• Q7M4L2
• Q8WTZ2
• IFN-R-1

Gene Name

• IFNAR1

Ensembl ID

• ENST00000270139
• ENSP00000270139
• ENSG00000142166

Symbol

• IFNAR
• AVP
• IFRC
• IFNAR
• IFNBR
• IFN-alpha-REC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
hub protein	0.85
transcription factor perturbation	0.84
cell type or tissue	0.82
transcription factor binding site profile	0.82

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Alpha/beta Receptor 1

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interferon Alpha/beta Receptor 1

Protein / Defense/immunity Protein / Interferon Alpha/beta Receptor 1

DTO Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Alpha/beta Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 912.37   (req: < 5)

Gene RIFs: 125   (req: <= 3)

Antibodies: 728   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 912.37   (req: >= 5)

Gene RIFs: 125   (req: > 3)

Antibodies: 728   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7