Tclin IFNAR1 Interferon alpha/beta receptor 1

Protein Summary

Description

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P17181
• B2R6L9
• B4DNT3
• D3DSF0
• Q53GW9
• Q53H11
• Q6PKD7
• Q7M4L2
• Q8WTZ2
• IFN-R-1

Gene Name

• IFNAR1

Ensembl ID

• ENST00000270139
• ENSP00000270139
• ENSG00000142166

Symbol

• IFNAR
• AVP
• IFRC
• IFNAR
• IFNBR
• IFN-alpha-REC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
hub protein	0.85
transcription factor perturbation	0.84
cell type or tissue	0.82
transcription factor binding site profile	0.82

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Alpha/beta Receptor 1

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interferon Alpha/beta Receptor 1

Protein / Defense/immunity Protein / Interferon Alpha/beta Receptor 1

DTO Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Alpha/beta Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 742.84   (req: < 5)

Gene RIFs: 99   (req: <= 3)

Antibodies: 728   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 742.84   (req: >= 5)

Gene RIFs: 99   (req: > 3)

Antibodies: 728   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (6)

Explore Approved Drugs

1 – 6 of 6

peginterferon beta-1a

IFNAR1Tclin

AGONIST :

interferon beta-1a

IFNAR1Tclin

AGONIST :

interferon beta-1b

IFNAR1Tclin

AGONIST :

peginterferon alfa-2a

IFNAR1Tclin

AGONIST :

peginterferon alfa-2b

IFNAR1Tclin

AGONIST :

ropeginterferon alfa-2b

IFNAR1Tclin

BINDING AGENT :

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (208)

Explore Interacting Targets

1 – 10 of 208

• See Interactions on String-DB

IFNB1

Tbio

Novelty:  0.00011797

p_int:  0.999940554

p_ni:  0.000059445

p_wrong:  1e-9

Score:  0.996

Data Source:  BioPlex,Reactome,STRINGDB

BTRC

Tbio

Novelty:  0.00293475

p_int:  0.999866272

p_ni:  0.000133727

p_wrong:  1e-9

Score:  0.456

Data Source:  BioPlex,STRINGDB

TNFRSF10A

Tchem

Novelty:  0.0003383

p_int:  0.999623925

p_ni:  0.000376073

p_wrong:  2e-9

Score:  0.244

Data Source:  BioPlex,STRINGDB

CTLA4

Tclin

Novelty:  0.00012781

p_int:  0.999162067

p_ni:  0.000586131

p_wrong:  0.000251801

Score:  0.398

Data Source:  BioPlex,STRINGDB

TYK2

Tclin

Family:  Kinase

Novelty:  0.00237955

Score:  0.998

Data Source:  Reactome,STRINGDB

IFNAR2

Tclin

Novelty:  0.00453303

Score:  0.998

Data Source:  Reactome,STRINGDB

IFNA2

Tbio

Novelty:  0.00032935

Score:  0.994

Data Source:  STRINGDB

CCNE1

Tchem

Novelty:  0.00237201

Score:  0.993

Data Source:  STRINGDB

CDK2

Tchem

Family:  Kinase

Novelty:  0.00032118

Score:  0.993

Data Source:  STRINGDB

CDK4

Tclin

Family:  Kinase

Novelty:  0.00036742

Score:  0.993

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (245)

Reactome (5)

KEGG (17)

PathwayCommons (9)

WikiPathways (214)

Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interferon Signaling	280 targets	R-HSA-913531
Reactome	Interferon alpha/beta signaling	136 targets	R-HSA-909733
Reactome	Regulation of IFNA signaling	25 targets	R-HSA-912694

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interferon Signaling	280 targets	R-HSA-913531
Interferon alpha/beta signaling	136 targets	R-HSA-909733
Regulation of IFNA signaling	25 targets	R-HSA-912694

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (2)

Components (4)

Processes (6)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
type I interferon receptor activity	Inferred from Direct Assay (IDA)	UniProtKB
type I interferon binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (10)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Crohn's disease	EFO_0000384	2	1	0	1.1	67.8
interleukin-10 receptor B measurement	EFO_0010786	1	1	1		64
COVID-19	MONDO_0100096	1	1	0	1.2	52.7
eosinophil count	EFO_0004842	1	1	1		42.3
eosinophil percentage of leukocytes	EFO_0007991	1	1	1		38.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Crohn's disease	EFO_0000384	0	1.1	67.8
interleukin-10 receptor B measurement	EFO_0010786	1		64
COVID-19	MONDO_0100096	0	1.2	52.7
eosinophil count	EFO_0004842	1		42.3
eosinophil percentage of leukocytes	EFO_0007991	1		38.8

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Endosome
Glycoprotein
Isopeptide bond
Lipoprotein
Lysosome

GWAS Trait Find Similar Targets

No Header	No Header
COVID-19
Crohn's disease
eosinophil count
eosinophil percentage of leukocytes
inflammatory bowel disease
interleukin-10 receptor B measurement
multiple sclerosis
narcolepsy with cataplexy
psoriasis
rheumatoid arthritis

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging
neoplasm
skeleton phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	interferon alpha and beta receptor subunit 1	VGNC:7183	458516
Macaque	interferon alpha and beta receptor subunit 1		699604
Mouse	interferon (alpha and beta) receptor 1	MGI:107658	15975
Rat	interferon alpha and beta receptor subunit 1	RGD:1305399	288264
Dog	interferon alpha/beta receptor 1		609830

Species	Name	OMA	EggNOG	Inparanoid
Chimp	interferon alpha and beta receptor subunit 1
Macaque	interferon alpha and beta receptor subunit 1
Mouse	interferon (alpha and beta) receptor 1
Rat	interferon alpha and beta receptor subunit 1
Dog	interferon alpha/beta receptor 1

Publication Statistics

PubMed Score 742.84

PubMed score by year

Reset Zoom

PubTator Score 237.53

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (145)

GeneRif Annotations (99)

Items per page:

10

0 of 0

PMID	Year	Title