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Tbio
GOT1
Aspartate aminotransferase, cytoplasmic

Protein Summary
Description
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370508
  • ENSP00000359539
  • ENSG00000120053

Symbol
  • AST1
  • cCAT
  • GIG18
  • cAspAT
  • ASTQTL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor binding site profile
0.9
histone modification site profile
0.89
transcription factor perturbation
0.88
virus perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.99   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 508   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.99   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 508   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
1
47.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
47.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamic-oxaloacetic transaminase 1
VGNC:9735
450664
Macaque
glutamic-oxaloacetic transaminase 1
708434
Mouse
MGI:95791
14718
Rat
RGD:2721
24401
Dog
glutamic-oxaloacetic transaminase 1
VGNC:41354
486834
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamic-oxaloacetic transaminase 1
Macaque
glutamic-oxaloacetic transaminase 1
Mouse
Rat
Dog
glutamic-oxaloacetic transaminase 1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (37)
Aspartate and asparagine metabolism (R-HSA-8963693)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aspartate and asparagine metabolism
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Aspartate and asparagine metabolism
Gluconeogenesis
Glucose metabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (37)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (168)
1 – 10 of 168
GOT1L1
Tdark
Family: Enzyme
Novelty: 0.52342415
p_int: 0.977495415
p_ni: 0.022504585
Score: 0.71
Data Source: BioPlex,STRINGDB
MDH1
Tbio
Family: Enzyme
Novelty: 0.00203876
Score: 0.99
Data Source: STRINGDB
GPT2
Tbio
Family: Enzyme
Novelty: 0.00478585
Score: 0.983
Data Source: STRINGDB
GLUD1
Tbio
Family: Enzyme
Novelty: 0.00301109
Score: 0.979
Data Source: STRINGDB
GLUD2
Tbio
Family: Enzyme
Novelty: 0.01470266
Score: 0.978
Data Source: STRINGDB
GPT
Tbio
Family: Enzyme
Novelty: 0.00003498
Score: 0.97
Data Source: STRINGDB
ALDH4A1
Tbio
Family: Enzyme
Novelty: 0.01316227
Score: 0.969
Data Source: STRINGDB
MDH2
Tchem
Family: Enzyme
Novelty: 0.00217694
Score: 0.964
Data Source: STRINGDB
PC
Tbio
Family: Enzyme
Novelty: 0.00271694
Score: 0.96
Data Source: STRINGDB
CAD
Tchem
Novelty: 0.00651422
Score: 0.959
Data Source: STRINGDB
Publication Statistics
PubMed Score  215.99

PubMed score by year
PubTator Score  85.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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