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Tbio
TMEM11
Transmembrane protein 11, mitochondrial

Protein Summary
Description
Plays a role in mitochondrial morphogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317635
  • ENSP00000319992
  • ENSG00000178307

Symbol
  • C17orf35
  • PM1
  • PM1
  • PMI
  • C17orf35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.98
transcription factor binding site profile
0.89
kinase perturbation
0.88
cellular component
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1561.75   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1561.75   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
CD8B
Tbio
Novelty:  0.00382722
p_int:  0.998882606
p_ni:  0.00111738
p_wrong:  1.5e-8
Data Source:  BioPlex
P2RY8
Tbio
Family:  GPCR
Novelty:  0.05574297
p_int:  0.994144067
p_ni:  0.005588705
p_wrong:  0.000267228
Data Source:  BioPlex
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.993699797
p_ni:  0.006198044
p_wrong:  0.000102159
Data Source:  BioPlex
BCAM
Tbio
Novelty:  0.01697541
p_int:  0.993520126
p_ni:  0.006447687
p_wrong:  0.000032187
Data Source:  BioPlex
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.99104521
p_ni:  0.008948849
p_wrong:  0.00000594
Data Source:  BioPlex
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.990986742
p_ni:  0.00901144
p_wrong:  0.000001818
Data Source:  BioPlex
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.988818921
p_ni:  0.008313611
p_wrong:  0.002867469
Data Source:  BioPlex
AGTR1
Tclin
Family:  GPCR
Novelty:  0.00033439
p_int:  0.983876701
p_ni:  0.006456061
p_wrong:  0.009667238
Score:  0.181
Data Source:  BioPlex,STRINGDB
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.982393233
p_ni:  0.017604619
p_wrong:  0.000002148
Data Source:  BioPlex
BNIP3
Tbio
Novelty:  0.00216392
p_int:  0.974823502
p_ni:  0.025162983
p_wrong:  0.000013515
Score:  0.281
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
2
2
73.4
reticulocyte measurement
1
1
1
48.3
red blood cell distribution width
4
1
4
44
hematocrit
1
1
1
40.7
mean reticulocyte volume
1
1
1
26.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
73.4
reticulocyte measurement
1
48.3
red blood cell distribution width
4
44
hematocrit
1
40.7
mean reticulocyte volume
1
26.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 11
VGNC:9723
454513
Macaque
transmembrane protein 11 [Source:HGNC Symbol;Acc:HGNC:16823]
Mouse
MGI:2144726
216821
Rat
RGD:1309817
303196
Dog
transmembrane protein 11
VGNC:47451
479532
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 11
Macaque
transmembrane protein 11 [Source:HGNC Symbol;Acc:HGNC:16823]
Mouse
Rat
Dog
transmembrane protein 11
Publication Statistics
PubMed Score 1561.75
PubMed score by year
PubTator Score 368.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title