Tdark ZNF8 Zinc finger protein 8

Protein Classes

DTO Classes

Zinc Finger Protein 862 / Zinc Finger Protein 821 / Putative Zinc Finger Protein 840 / Zinc Finger Protein 836 / Zinc Finger Protein 891 / Zinc Finger Protein 835 / Zinc Finger Protein 80 / Zinc Finger Protein 846 / Zinc Finger Protein 841 / Zinc Finger Protein 827

Protein Summary

Description

Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins.

Uniprot Accession IDs

• P17098
• Q6PI99

Gene Name

• ZNF8

Ensembl ID

• ENST00000621650
• ENSP00000477716
• ENSG00000278129

Symbol

• HF.18
• Zfp128

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
co-expressed gene	0.76
cell type or tissue	0.69
cell line	0.6
protein domain	0.58

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.77   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.77   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (1)

KEGG (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Herpes simplex virus 1 infection	567 targets	path:hsa05168

Name	Explore in Pharos	Explore in Source
Herpes simplex virus 1 infection	567 targets	path:hsa05168

Gene Ontology Terms (5)

Functions (2)

Components (1)

Processes (2)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
DNA binding	Non-traceable Author Statement (NAS)	UniProtKB
zinc ion binding	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (17)

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1 – 10 of 17

• See Interactions on String-DB

VWCE

Tbio

Novelty: 0.10129635

p_int: 0.99989799

p_ni: 5.31e-7

p_wrong: 0.000101479

Score: 0.251

Data Source: BioPlex,STRINGDB

PTPN12

Tchem

Family: Enzyme

Novelty: 0.01537047

Score: 0.628

Data Source: STRINGDB

GFER

Tchem

Family: Enzyme

Novelty: 0.00073821

Score: 0.594

Data Source: STRINGDB

EPHB2

Tchem

Family: Kinase

Novelty: 0.00187689

Score: 0.55

Data Source: STRINGDB

MSH6

Tbio

Family: Epigenetic

Novelty: 0.00148002

Score: 0.544

Data Source: STRINGDB

MSH3

Tbio

Novelty: 0.00139708

Score: 0.531

Data Source: STRINGDB

TPST2

Tbio

Family: Enzyme

Novelty: 0.03075981

Score: 0.501

Data Source: STRINGDB

RSPRY1

Tdark

Novelty: 0.46153846

Score: 0.478

Data Source: STRINGDB

ODF4

Tbio

Novelty: 0.14671557

Score: 0.476

Data Source: STRINGDB

FAM71C

Tdark

Score: 0.475

Data Source: STRINGDB

Publication Statistics

PubMed Score  0.77

PubMed score by year

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PubTator Score  2.6

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Reference proteome
Repeat
Transcription
Transcription regulation
Ubl conjugation