Tdark ZNF8 Zinc finger protein 8

Protein Summary

Description

Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins.

Uniprot Accession IDs

• P17098
• Q6PI99

Gene Name

• ZNF8

Ensembl ID

• ENST00000621650
• ENSP00000477716
• ENSG00000278129

Symbol

• HF.18
• Zfp128

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
co-expressed gene	0.76
cell type or tissue	0.69
cell line	0.6
protein domain	0.58

Protein Classes

DTO Classes

Zinc Finger Protein 862 / Zinc Finger Protein 821 / Putative Zinc Finger Protein 840 / Zinc Finger Protein 836 / Zinc Finger Protein 891 / Zinc Finger Protein 835 / Zinc Finger Protein 80 / Zinc Finger Protein 846 / Zinc Finger Protein 841 / Zinc Finger Protein 827

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.3   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.3   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (17)

Explore Interacting Targets

1 – 10 of 17

• See Interactions on String-DB

VWCE

Tbio

Novelty:  0.09328341

p_int:  0.99989799

p_ni:  5.31e-7

p_wrong:  0.000101479

Score:  0.251

Data Source:  BioPlex,STRINGDB

PTPN12

Tchem

Family:  Enzyme

Novelty:  0.01333491

Score:  0.628

Data Source:  STRINGDB

GFER

Tchem

Family:  Enzyme

Novelty:  0.00338563

Score:  0.594

Data Source:  STRINGDB

EPHB2

Tchem

Family:  Kinase

Novelty:  0.00211785

Score:  0.55

Data Source:  STRINGDB

MSH6

Tbio

Family:  Epigenetic

Novelty:  0.00097439

Score:  0.544

Data Source:  STRINGDB

MSH3

Tbio

Novelty:  0.0036266

Score:  0.531

Data Source:  STRINGDB

TPST2

Tbio

Family:  Enzyme

Novelty:  0.02551048

Score:  0.501

Data Source:  STRINGDB

RSPRY1

Tdark

Novelty:  0.26883105

Score:  0.478

Data Source:  STRINGDB

ODF4

Tbio

Novelty:  0.13423621

Score:  0.476

Data Source:  STRINGDB

FAM71C

Tdark

Novelty:  5.35081241

Score:  0.475

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Herpes simplex virus 1 infection	567 targets	path:hsa05168

Name	Explore in Pharos	Explore in Source
Herpes simplex virus 1 infection	567 targets	path:hsa05168

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (2)

Components (1)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
DNA binding	Non-traceable Author Statement (NAS)	UniProtKB
zinc ion binding	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Reference proteome
Repeat
Transcription
Transcription regulation
Ubl conjugation

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 8	VGNC:2121	469052
Macaque	zinc finger protein 8		712592
Mouse	zinc finger protein 128	MGI:2389445	243833
Horse	zinc finger protein 8	VGNC:25391	100051604

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 8
Macaque	zinc finger protein 8
Mouse	zinc finger protein 128
Horse	zinc finger protein 8

Publication Statistics

PubMed Score 2.30

PubMed score by year

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PubTator Score 2.60

PubTator score by year

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Related Publications

Text Mined References (8)

Items per page:

10

0 of 0

PMID	Year	Title