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Tdark
ZNF8
Zinc finger protein 8

Protein Summary
Description
Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000621650
  • ENSP00000477716
  • ENSG00000278129

Symbol
  • HF.18
  • Zfp128
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
co-expressed gene
0.76
cell type or tissue
0.69
cell line
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.3   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.3   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.99989799
p_ni:  5.31e-7
p_wrong:  0.000101479
Score:  0.251
Data Source:  BioPlex,STRINGDB
PTPN12
Tchem
Family:  Enzyme
Novelty:  0.01333491
Score:  0.628
Data Source:  STRINGDB
GFER
Tchem
Family:  Enzyme
Novelty:  0.00338563
Score:  0.594
Data Source:  STRINGDB
EPHB2
Tchem
Family:  Kinase
Novelty:  0.00211785
Score:  0.55
Data Source:  STRINGDB
MSH6
Tbio
Family:  Epigenetic
Novelty:  0.00097439
Score:  0.544
Data Source:  STRINGDB
MSH3
Tbio
Novelty:  0.0036266
Score:  0.531
Data Source:  STRINGDB
TPST2
Tbio
Family:  Enzyme
Novelty:  0.02551048
Score:  0.501
Data Source:  STRINGDB
RSPRY1
Tdark
Novelty:  0.26883105
Score:  0.478
Data Source:  STRINGDB
ODF4
Tbio
Novelty:  0.13423621
Score:  0.476
Data Source:  STRINGDB
FAM71C
Tdark
Novelty:  5.35081241
Score:  0.475
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 8
VGNC:2121
469052
Macaque
zinc finger protein 8
712592
Mouse
MGI:2389445
243833
Horse
zinc finger protein 8
VGNC:25391
100051604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 8
Macaque
zinc finger protein 8
Mouse
Horse
zinc finger protein 8
Publication Statistics
PubMed Score 2.30
PubMed score by year
PubTator Score 2.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title