Tbio HMGA1 High mobility group protein HMG-I/HMG-Y

Protein Summary

Description

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P17096
• P10910
• Q5T6U9
• Q9UKB0
• HMG-I(Y)

Gene Name

• HMGA1

Ensembl ID

• ENST00000311487
• ENSP00000308227
• ENSG00000137309
• ENST00000347617
• ENSP00000288245
• ENST00000374116
• ENSP00000363230
• ENST00000401473
• ENSP00000385693
• ENST00000447654
• ENSP00000399888

Symbol

• HMGIY
• HMG-R
• HMGIY
• HMGA1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.97
transcription factor	0.95
interacting protein	0.94
transcription factor binding site profile	0.94
biological process	0.91

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / High Mobility Group Protein Hmg-i/hmg-y

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / High Mobility Group Protein Hmg-i/hmg-y

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 717.53   (req: < 5)

Gene RIFs: 219   (req: <= 3)

Antibodies: 342   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 717.53   (req: >= 5)

Gene RIFs: 219   (req: > 3)

Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0