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Tbio
HMGA1
High mobility group protein HMG-I/HMG-Y

Protein Summary
Description
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311487
  • ENSP00000308227
  • ENSG00000137309
  • ENST00000347617
  • ENSP00000288245
  • ENST00000374116
  • ENSP00000363230
  • ENST00000401473
  • ENSP00000385693
  • ENST00000447654
  • ENSP00000399888

Symbol
  • HMGIY
  • HMG-R
  • HMGIY
  • HMGA1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.97
transcription factor
0.95
interacting protein
0.94
transcription factor binding site profile
0.94
biological process
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 632.78   (req: < 5)
Gene RIFs: 151   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 632.78   (req: >= 5)
Gene RIFs: 151   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
68.3
mean reticulocyte volume
1
1
1
46.2
platelet crit
1
1
1
21
monocyte count
1
1
1
17.5
lymphocyte count
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
68.3
mean reticulocyte volume
1
46.2
platelet crit
1
21
monocyte count
1
17.5
lymphocyte count
1
17.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
high mobility group AT-hook 1
VGNC:3119
746594
Mouse
MGI:96160
15361
Rat
RGD:628699
117062
Dog
high mobility group AT-hook 1
VGNC:41709
442946
Horse
high mobility group AT-hook 1
VGNC:18802
100629238
Species
Name
OMA
EggNOG
Inparanoid
Chimp
high mobility group AT-hook 1
Mouse
Rat
Dog
high mobility group AT-hook 1
Horse
high mobility group AT-hook 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P17096-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (39)
2-LTR circle formation (R-HSA-164843)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
2-LTR circle formation
Reactome
APOBEC3G mediated resistance to HIV-1 infection
Reactome
Autointegration results in viral DNA circles
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
2-LTR circle formation
APOBEC3G mediated resistance to HIV-1 infection
Autointegration results in viral DNA circles
Cellular Senescence
Cellular responses to external stimuli
Gene Ontology Terms (37)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (97)
1 – 10 of 97
VRK3
Tbio
Family: Kinase
Novelty: 0.15665279
p_int: 0.999994519
p_ni: 0.00000548
p_wrong: 1e-9
Data Source: BioPlex
CABIN1
Tbio
Novelty: 0.02528794
p_int: 0.999978195
p_ni: 0.000021805
Score: 0.903
Data Source: BioPlex,Reactome,STRINGDB
HIRA
Tbio
Novelty: 0.01362595
p_int: 0.999969331
p_ni: 0.000030669
Score: 0.902
Data Source: BioPlex,Reactome,STRINGDB
UBN2
Tbio
Novelty: 0.09777456
p_int: 0.999590408
p_ni: 0.000409592
Data Source: BioPlex
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.999373707
p_ni: 0.000626291
p_wrong: 3e-9
Score: 0.332
Data Source: BioPlex,STRINGDB
C1QBP
Tbio
Novelty: 0.00532825
p_int: 0.995351153
p_ni: 0.004648847
Score: 0.166
Data Source: BioPlex,STRINGDB
PARP2
Tclin
Family: Enzyme
Novelty: 0.00545618
p_int: 0.995168598
p_ni: 0.004831391
p_wrong: 1.1e-8
Data Source: BioPlex
XPC
Tbio
Novelty: 0.00775175
p_int: 0.960418964
p_ni: 0.039581036
Data Source: BioPlex
H2AFY
Tbio
Novelty: 0.01150729
p_int: 0.946864094
p_ni: 0.053135873
p_wrong: 3.2e-8
Data Source: BioPlex
HIST1H2AG
Tbio
Novelty: 0.03331195
p_int: 0.86790883
p_ni: 0.13209117
Data Source: BioPlex
Publication Statistics
PubMed Score  632.78

PubMed score by year
PubTator Score  404.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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