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Tbio
RHOQ
Rho-related GTP-binding protein RhoQ

Protein Summary
Description
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238738
  • ENSP00000238738
  • ENSG00000119729

Symbol
  • ARHQ
  • RASL7A
  • TC10
  • ARHQ
  • TC10
  • TC10A
  • RASL7A
  • HEL-S-42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
molecular function
0.95
virus perturbation
0.9
biological process
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.89   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.89   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (247)
1 – 10 of 247
EXOC7
Tbio
Novelty:  0.00852508
Score:  0.966
Data Source:  STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
Score:  0.966
Data Source:  STRINGDB
MCF2
Tbio
Novelty:  0.00345951
Score:  0.966
Data Source:  STRINGDB
ARHGDIA
Tchem
Novelty:  0.001991
Score:  0.966
Data Source:  STRINGDB
VAV1
Tchem
Novelty:  0.00180518
Score:  0.964
Data Source:  STRINGDB
RAPGEF1
Tbio
Novelty:  0.00365765
Score:  0.962
Data Source:  STRINGDB
TIAM1
Tbio
Novelty:  0.00431726
Score:  0.961
Data Source:  STRINGDB
ARHGAP35
Tbio
Family:  Enzyme
Novelty:  0.00970784
Score:  0.96
Data Source:  STRINGDB
VAV3
Tbio
Novelty:  0.010944
Score:  0.958
Data Source:  STRINGDB
VAV2
Tbio
Novelty:  0.01062502
Score:  0.958
Data Source:  STRINGDB
Pathways (14)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases regulate CFTR trafficking
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RHO GTPase Effectors
RHO GTPases regulate CFTR trafficking
Rho GTPase cycle
Signal Transduction
Gene Ontology Terms (31)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gait measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gait measurement
1
17.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ras homolog family member Q
717769
Mouse
MGI:1931553
104215
Rat
RGD:621626
85428
Dog
ras homolog family member Q
VGNC:54538
474579
Horse
ras homolog family member Q
VGNC:51398
100068479
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ras homolog family member Q
Mouse
Rat
Dog
ras homolog family member Q
Horse
ras homolog family member Q
Publication Statistics
PubMed Score 137.89
PubMed score by year
PubTator Score 44.56
PubTator score by year