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Tbio
HSPA6
Heat shock 70 kDa protein 6

Protein Summary
Description
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and rel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309758
  • ENSP00000310219
  • ENSG00000173110

Symbol
  • HSP70B'
  • HSP70B'
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
1
hub protein
0.96
molecular function
0.96
virus perturbation
0.9


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.41   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.41   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Horse
heat shock protein family A (Hsp70) member 6
100051595
Cow
heat shock protein family A (Hsp70) member 6
539835
S.cerevisiae
S000000171
852203
Species
Name
OMA
EggNOG
Inparanoid
Horse
heat shock protein family A (Hsp70) member 6
Cow
heat shock protein family A (Hsp70) member 6
S.cerevisiae
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (73)
Attenuation phase (R-HSA-3371568)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSF1 activation
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
HSF1 activation
Gene Ontology Terms (24)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (188)
1 – 10 of 188
PRODH
Tbio
Family: Enzyme
Novelty: 0.00315806
p_int: 0.954077385
p_ni: 0.045922615
Score: 0.234
Data Source: BioPlex,STRINGDB
FUK
Tbio
Family: Kinase
Novelty: 0.05169095
p_int: 0.893354618
p_ni: 0.106645382
Data Source: BioPlex
SOHLH1
Tbio
Family: TF
Novelty: 0.04218087
p_int: 0.881478359
p_ni: 0.118521641
Data Source: BioPlex
ILK
Tchem
Family: Kinase
Novelty: 0.00147344
p_int: 0.870903695
p_ni: 0.129096305
Score: 0.279
Data Source: BioPlex,STRINGDB
NOXO1
Tbio
Family: Enzyme
Novelty: 0.02648748
p_int: 0.858571443
p_ni: 0.141428557
Data Source: BioPlex
NTNG1
Tbio
Novelty: 0.04742965
p_int: 0.851978578
p_ni: 0.148021422
Score: 0.309
Data Source: BioPlex,STRINGDB
TTC30B
Tbio
Novelty: 0.10944566
p_int: 0.822465331
p_ni: 0.177534669
Score: 0.159
Data Source: BioPlex,STRINGDB
MOCS3
Tbio
Family: Enzyme
Novelty: 0.039209
p_int: 0.820818646
p_ni: 0.179181354
Score: 0.222
Data Source: BioPlex,STRINGDB
CERCAM
Tdark
Family: Enzyme
Novelty: 0.33392502
p_int: 0.806579137
p_ni: 0.193420863
Data Source: BioPlex
KLHL34
Tdark
Novelty: 2.18471039
p_int: 0.796959829
p_ni: 0.203040171
Score: 0.155
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  153.41

PubMed score by year
PubTator Score  19.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer