You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NAGA
Alpha-N-acetylgalactosaminidase

Protein Summary
Description
Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids. NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396398
  • ENSP00000379680
  • ENSG00000198951
  • ENST00000402937
  • ENSP00000384603
  • ENST00000403363
  • ENSP00000385283

Symbol
  • GALB
  • D22S674
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.88
transcription factor perturbation
0.88
protein domain
0.73
tissue sample
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.47   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.47   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (62)
1 – 10 of 62
SLAMF1
Tbio
Novelty:  0.00112892
p_int:  0.814218958
p_ni:  0.185780989
p_wrong:  5.2e-8
Data Source:  BioPlex
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.788089029
p_ni:  0.211910971
Score:  0.341
Data Source:  BioPlex,STRINGDB
HEXA
Tchem
Family:  Enzyme
Novelty:  0.01134783
Score:  0.953
Data Source:  STRINGDB
B3GALNT1
Tbio
Family:  Enzyme
Novelty:  0.01235828
Score:  0.947
Data Source:  STRINGDB
HEXB
Tchem
Family:  Enzyme
Novelty:  0.0085045
Score:  0.943
Data Source:  STRINGDB
B3GALT5
Tbio
Family:  Enzyme
Novelty:  0.04158039
Score:  0.9
Data Source:  STRINGDB
ACO2
Tbio
Family:  Enzyme
Novelty:  0.00276725
Score:  0.769
Data Source:  STRINGDB
OGA
Tchem
Family:  Enzyme
Novelty:  0.00035723
Score:  0.726
Data Source:  STRINGDB
MAN2B1
Tchem
Family:  Enzyme
Novelty:  0.0051017
Score:  0.702
Data Source:  STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
Score:  0.697
Data Source:  STRINGDB
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Lysosome
KEGG
Metabolic pathways
KEGG
Glycosphingolipid biosynthesis - globo and isoglobo series
Name
Explore in Pharos
Explore in Source
Lysosome
Metabolic pathways
Glycosphingolipid biosynthesis - globo and isoglobo series
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
6
9
2
6
85.3
self reported educational attainment
3
3
3
80.7
3
3
1
1.1
80.7
cognitive function measurement
3
2
3
78.2
mathematical ability
2
2
2
63
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
6
85.3
self reported educational attainment
3
80.7
1
1.1
80.7
cognitive function measurement
3
78.2
mathematical ability
2
63
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha-N-acetylgalactosaminidase
VGNC:10397
470279
Macaque
alpha-N-acetylgalactosaminidase
713068
Mouse
MGI:1261422
17939
Rat
RGD:1306025
315165
Dog
alpha-N-acetylgalactosaminidase
VGNC:43608
481226
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha-N-acetylgalactosaminidase
Macaque
alpha-N-acetylgalactosaminidase
Mouse
Rat
Dog
alpha-N-acetylgalactosaminidase
Publication Statistics
PubMed Score 167.47
PubMed score by year
PubTator Score 224.07
PubTator score by year