Tbio ZNF12 Zinc finger protein 12

Protein Summary

Description

Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity. This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P17014
• A8MYC4
• A8WFQ8
• B2RNQ7
• B4DF45
• Q6N016
• Q8NHZ0
• Q9H9P0
• Q9ULZ6

Gene Name

• ZNF12

Ensembl ID

• ENST00000342651
• ENSP00000344745
• ENSG00000164631
• ENST00000404360
• ENSP00000384405
• ENST00000405858
• ENSP00000385939

Symbol

• GIOT3
• KOX3
• ZNF325
• KOX3
• HZF11
• GIOT-3
• ZNF325

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
histone modification site profile	0.7
transcription factor binding site profile	0.67
protein domain	0.58
tissue	0.57

Protein Classes

DTO Classes

Zinc Finger Protein 124

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.36   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.36   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0