ZNF12
Zinc finger protein 12
Protein Summary
Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity. This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- ENST00000342651
- ENSP00000344745
- ENSG00000164631
- ENST00000404360
- ENSP00000384405
- ENST00000405858
- ENSP00000385939
- GIOT3
- KOX3
- ZNF325
- KOX3
- HZF11
- GIOT-3
- ZNF325
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.79 | ||
histone modification site profile | 0.7 | ||
transcription factor binding site profile | 0.67 | ||
protein domain | 0.58 | ||
tissue | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.09 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 91 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.09 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 91 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (15)
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (3)
Components (3)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 3 | 3 | 84.4 | |||||
IGF-1 measurement | 1 | 3 | 3 | 80.7 | |||||
myeloid white cell count | 1 | 1 | 1 | 74.6 | |||||
sex hormone-binding globulin measurement | 3 | 2 | 3 | 69.3 | |||||
hematocrit | 3 | 2 | 3 | 67.1 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 84.4 | |||||
IGF-1 measurement | 3 | 80.7 | |||||
myeloid white cell count | 1 | 74.6 | |||||
sex hormone-binding globulin measurement | 3 | 69.3 | |||||
hematocrit | 3 | 67.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | zinc finger protein 12 | 463251 | ||||||
Macaque | zinc finger protein 12 | 705346 | ||||||
Mouse | MGI:99157 | 231866 | ||||||
Dog | zinc finger protein 12 | VGNC:48656 | 100683482 | |||||
Horse | zinc finger protein 12 | VGNC:25260 | 100061429 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | zinc finger protein 12 | |||||
Macaque | zinc finger protein 12 | |||||
Mouse | ||||||
Dog | zinc finger protein 12 | |||||
Horse | zinc finger protein 12 | |||||
Publication Statistics
PubMed Score 5.09
PubMed score by year
PubTator Score 3.11
PubTator score by year
Related Publications
Text Mined References (7)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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