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Tbio
STMN1
Stathmin

Protein Summary
Description
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357865
  • ENSP00000350531
  • ENSG00000117632
  • ENST00000374291
  • ENSP00000363409
  • ENST00000399728
  • ENSP00000382633
  • ENST00000426559
  • ENSP00000410452
  • ENST00000455785
  • ENSP00000387858

Symbol
  • C1orf215
  • LAP18
  • OP18
  • Lag
  • SMN
  • OP18
  • PP17
  • PP19
  • PR22
  • LAP18
  • C1orf215
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
1
kinase perturbation
1
PubMedID
0.99
hub protein
0.98
ligand (protein) perturbation
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 953.98   (req: < 5)
Gene RIFs: 175   (req: <= 3)
Antibodies: 1329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 953.98   (req: >= 5)
Gene RIFs: 175   (req: > 3)
Antibodies: 1329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
66.6
red blood cell density measurement
1
1
1
64.9
hematocrit
2
2
2
63.6
waist-hip ratio
1
1
1
48.5
BMI-adjusted waist-hip ratio
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
66.6
red blood cell density measurement
1
64.9
hematocrit
2
63.6
waist-hip ratio
1
48.5
BMI-adjusted waist-hip ratio
1
42.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stathmin 1
VGNC:53215
456650
Macaque
stathmin 1
719733
Mouse
MGI:96739
16765
Rat
RGD:2992
29332
Dog
stathmin 1
VGNC:46925
478175
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stathmin 1
Macaque
stathmin 1
Mouse
Rat
Dog
stathmin 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P16949-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Nuclear signaling by ERBB4 (R-HSA-1251985)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Nuclear signaling by ERBB4
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Nuclear signaling by ERBB4
Signal Transduction
Signaling by ERBB4
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (27)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (164)
1 – 10 of 164
STMN3
Tbio
Novelty:  0.05061958
p_int:  0.999926868
p_ni:  0.00007303
p_wrong:  1.02e-7
Score:  0.168
Data Source:  BioPlex,STRINGDB
STMN2
Tbio
Novelty:  0.00854367
p_int:  0.989114607
p_ni:  0.010885393
Score:  0.561
Data Source:  BioPlex,STRINGDB
GBP2
Tbio
Novelty:  0.01803054
p_int:  0.960143208
p_ni:  0.037345987
p_wrong:  0.002510805
Data Source:  BioPlex
RPS4Y1
Tbio
p_int:  0.752945964
p_ni:  0.246139964
p_wrong:  0.000914073
Data Source:  BioPlex
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.99
Data Source:  STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
Score:  0.968
Data Source:  STRINGDB
TUBA1A
Tchem
Novelty:  0.01030145
Score:  0.965
Data Source:  STRINGDB
TUBA1C
Tchem
Novelty:  0.02804632
Score:  0.962
Data Source:  STRINGDB
AURKB
Tchem
Family:  Kinase
Novelty:  0.00100972
Score:  0.954
Data Source:  STRINGDB
CCNB1
Tchem
Novelty:  0.0005503
Score:  0.954
Data Source:  STRINGDB
Publication Statistics
PubMed Score  953.98

PubMed score by year
PubTator Score  560.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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