PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
biological process | 0.98 | ||
hub protein | 0.97 | ||
PubMedID | 0.94 | ||
metabolite | 0.89 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | CLEC7A (Dectin-1) signaling | ||||
Reactome | DAP12 interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
C-type lectin receptors (CLRs) | ||||
CLEC7A (Dectin-1) signaling | ||||
DAP12 interactions | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Traceable Author Statement (TAS) | Reactome | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 4 | 6 | 98.1 | |||||
4 | 3 | 4 | 76.1 | ||||||
3 | 1 | 1 | 1.1 | 73.9 | |||||
vitamin D measurement | 3 | 1 | 3 | 67.1 | |||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 64.9 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean platelet volume | 6 | 98.1 | |||||
4 | 76.1 | ||||||
1 | 1.1 | 73.9 | |||||
vitamin D measurement | 3 | 67.1 | |||||
comparative body size at age 10, self-reported | 1 | 64.9 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | phospholipase C gamma 2 | VGNC:8991 | 454268 | |||||
Macaque | phospholipase C gamma 2 | 714173 | ||||||
Mouse | MGI:97616 | 234779 | ||||||
Rat | RGD:3348 | 29337 | ||||||
Dog | phospholipase C gamma 2 | VGNC:44652 | 489692 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | phospholipase C gamma 2 | |||||
Macaque | phospholipase C gamma 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | phospholipase C gamma 2 | |||||
PMID | Year | Title |
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