PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Protein Summary
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
- ENST00000564138
- ENSP00000482457
- ENSG00000197943
- FCAS3
- APLAID
- PLC-IV
- PLC-gamma-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
biological process | 0.98 | ||
hub protein | 0.97 | ||
PubMedID | 0.94 | ||
metabolite | 0.89 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 336.35 (req: < 5)
Gene RIFs: 46 (req: <= 3)
Antibodies: 932 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 336.35 (req: >= 5)
Gene RIFs: 46 (req: > 3)
Antibodies: 932 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (242)
Nearest Tclin Targets (22)
Upstream (13)
Downstream (9)
1 – 5 of 13
Pathways (112)
Reactome (26)
KEGG (35)
PathwayCommons (39)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | CLEC7A (Dectin-1) signaling | ||||
Reactome | DAP12 interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
C-type lectin receptors (CLRs) | ||||
CLEC7A (Dectin-1) signaling | ||||
DAP12 interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (3)
Components (3)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 4 | 6 | 98.1 | |||||
4 | 3 | 4 | 76.1 | ||||||
3 | 1 | 1 | 1.1 | 73.9 | |||||
vitamin D measurement | 3 | 1 | 3 | 67.1 | |||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 64.9 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 6 | 98.1 | |||||
4 | 76.1 | ||||||
1 | 1.1 | 73.9 | |||||
vitamin D measurement | 3 | 67.1 | |||||
comparative body size at age 10, self-reported | 1 | 64.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phospholipase C gamma 2 | VGNC:8991 | 454268 | |||||
Macaque | phospholipase C gamma 2 | 714173 | ||||||
Mouse | MGI:97616 | 234779 | ||||||
Rat | RGD:3348 | 29337 | ||||||
Dog | phospholipase C gamma 2 | VGNC:44652 | 489692 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phospholipase C gamma 2 | |||||
Macaque | phospholipase C gamma 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | phospholipase C gamma 2 | |||||
Publication Statistics
PubMed Score 336.35
PubMed score by year
PubTator Score 124.53
PubTator score by year
Related Publications
Text Mined References (113)
GeneRif Annotations (46)
Items per page:
0 of 0
PMID | Year | Title |
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