You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Protein Classes
Protein Summary
Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000564138
  • ENSP00000482457
  • ENSG00000197943

Symbol
  • FCAS3
  • APLAID
  • PLC-IV
  • PLC-gamma-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.98
hub protein
0.97
PubMedID
0.94
metabolite
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.13   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 932   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.13   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 932   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
3
1
1
1.1
93.4
mean platelet volume
3
4
6
92.5
4
3
4
75.6
late-onset Alzheimers disease
1
1
0
1.5
57.1
gut microbiome measurement
1
1
0
2.2
38.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
1.1
93.4
mean platelet volume
6
92.5
4
75.6
late-onset Alzheimers disease
0
1.5
57.1
gut microbiome measurement
0
2.2
38.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase C gamma 2
VGNC:8991
454268
Macaque
phospholipase C gamma 2
714173
Mouse
MGI:97616
234779
Rat
RGD:3348
29337
Dog
phospholipase C gamma 2
VGNC:44652
489692
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase C gamma 2
Macaque
phospholipase C gamma 2
Mouse
Rat
Dog
phospholipase C gamma 2
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (112)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
DAP12 interactions
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
DAP12 interactions
Protein-Protein Interactions (242)
1 – 10 of 242
BTK
Tclin
Family: Kinase
Novelty: 0.00050747
Score: 0.991
Data Source: Reactome,STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.991
Data Source: Reactome,STRINGDB
LCP2
Tbio
Novelty: 0.00512968
Score: 0.99
Data Source: Reactome,STRINGDB
ZAP70
Tchem
Family: Kinase
Novelty: 0.0011564
Score: 0.983
Data Source: Reactome,STRINGDB
BLNK
Tbio
Novelty: 0.00351169
Score: 0.982
Data Source: STRINGDB
LAT
Tbio
Novelty: 0.00738419
Score: 0.981
Data Source: Reactome,STRINGDB
DAPP1
Tbio
Novelty: 0.05145215
Score: 0.981
Data Source: Reactome,STRINGDB
FCER1G
Tbio
Novelty: 0.00783146
Score: 0.973
Data Source: Reactome,STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00179772
Score: 0.971
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  325.13

PubMed score by year
PubTator Score  124.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: