Tchem PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Protein Summary

Description

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• P16885
• D3DUL3
• Q3ZTS2
• Q59H45
• Q969T5

Gene Name

• PLCG2

Ensembl ID

• ENST00000564138
• ENSP00000482457
• ENSG00000197943

Symbol

• FCAS3
• APLAID
• PLC-IV
• PLC-gamma-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
biological process	0.98
hub protein	0.97
PubMedID	0.94
metabolite	0.89

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Gamma-2

Protein / Hydrolase / Lipase / Phospholipase / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Gamma-2

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Gamma-2

Protein / Calcium-binding Protein / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Gamma-2

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Gamma-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.39   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 932   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.39   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 932   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0