PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Protein Classes
Protein Summary
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
- ENST00000564138
- ENSP00000482457
- ENSG00000197943
- FCAS3
- APLAID
- PLC-IV
- PLC-gamma-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
biological process | 0.98 | ||
hub protein | 0.97 | ||
PubMedID | 0.94 | ||
metabolite | 0.89 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 336.35 (req: < 5)
Gene RIFs: 46 (req: <= 3)
Antibodies: 932 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 336.35 (req: >= 5)
Gene RIFs: 46 (req: > 3)
Antibodies: 932 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (3)
1 – 3 of 3
GWAS Traits (15)
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1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 4 | 6 | 98.1 | |||||
4 | 3 | 4 | 76.1 | ||||||
venous thromboembolism | 3 | 1 | 1 | 1.1 | 73.9 | ||||
vitamin D measurement | 3 | 1 | 3 | 67.1 | |||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 64.9 | |||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 6 | 98.1 | |||||
4 | 76.1 | ||||||
venous thromboembolism | 1 | 1.1 | 73.9 | ||||
vitamin D measurement | 3 | 67.1 | |||||
comparative body size at age 10, self-reported | 1 | 64.9 | |||||
Orthologs (11)
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Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phospholipase C gamma 2 | VGNC:8991 | 454268 | |||||
Macaque | phospholipase C gamma 2 | 714173 | ||||||
Mouse | MGI:97616 | 234779 | ||||||
Rat | RGD:3348 | 29337 | ||||||
Dog | phospholipase C gamma 2 | VGNC:44652 | 489692 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phospholipase C gamma 2 | |||||
Macaque | phospholipase C gamma 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | phospholipase C gamma 2 | |||||
Protein Structure (3 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (112)
Reactome (26)
KEGG (35)
PathwayCommons (39)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 26
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | CLEC7A (Dectin-1) signaling | ||||
Reactome | DAP12 interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
C-type lectin receptors (CLRs) | ||||
CLEC7A (Dectin-1) signaling | ||||
DAP12 interactions | ||||
Gene Ontology Terms (27)
Functions (3)
Components (3)
Processes (21)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (242)
1 – 10 of 242
BTK
Family: Kinase
Novelty: 0.00050747
Score: 0.991
Data Source: Reactome,STRINGDB
SYK
Family: Kinase
Novelty: 0.00058994
Score: 0.991
Data Source: Reactome,STRINGDB
LCP2
Novelty: 0.00512968
Score: 0.99
Data Source: Reactome,STRINGDB
ZAP70
Family: Kinase
Novelty: 0.0011564
Score: 0.983
Data Source: Reactome,STRINGDB
BLNK
Novelty: 0.00351169
Score: 0.982
Data Source: STRINGDB
LAT
Novelty: 0.00738419
Score: 0.981
Data Source: Reactome,STRINGDB
DAPP1
Novelty: 0.05145215
Score: 0.981
Data Source: Reactome,STRINGDB
FCER1G
Novelty: 0.00783146
Score: 0.973
Data Source: Reactome,STRINGDB
PIK3R1
Family: Kinase
Novelty: 0.00179772
Score: 0.971
Data Source: STRINGDB
SRC
Family: Kinase
Novelty: 0.00008479
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score 336.35
PubMed score by year
PubTator Score 124.53
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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GWAS Trait
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