IL7R
Interleukin-7 receptor subunit alpha
Protein Summary
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015]
- ENST00000303115
- ENSP00000306157
- ENSG00000168685
- ENST00000506850
- ENSP00000421207
- ILRA
- CD127
- IL7RA
- CDW127
- IL-7R-alpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
hub protein | 0.98 | ||
transcription factor perturbation | 0.97 | ||
biological process | 0.86 | ||
disease | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 894.7 (req: < 5)
Gene RIFs: 273 (req: <= 3)
Antibodies: 1128 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 894.7 (req: >= 5)
Gene RIFs: 273 (req: > 3)
Antibodies: 1128 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0