You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IL7R
Interleukin-7 receptor subunit alpha

Protein Summary
Description
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
hub protein
0.98
transcription factor perturbation
0.97
biological process
0.86
disease
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 778.44   (req: < 5)
Gene RIFs: 209   (req: <= 3)
Antibodies: 1128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 778.44   (req: >= 5)
Gene RIFs: 209   (req: > 3)
Antibodies: 1128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.1
98.1
5
3
0
1.1
96.6
Eczema
2
1
0
1.1
95.9
3
3
0
1.1
93.1
lymphocyte count
2
2
2
90.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
98.1
0
1.1
96.6
Eczema
0
1.1
95.9
0
1.1
93.1
lymphocyte count
2
90.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 7 receptor
VGNC:13516
461922
Macaque
interleukin 7 receptor
699869
Mouse
MGI:96562
16197
Rat
RGD:1309776
294797
Dog
interleukin 7 receptor
VGNC:41996
612582
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 7 receptor
Macaque
interleukin 7 receptor
Mouse
Rat
Dog
interleukin 7 receptor
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16871-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (373)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-7 signaling
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Cytokine Signaling in Immune system
Immune System
Interleukin-7 signaling
Protein-Protein Interactions (391)
1 – 10 of 391
FGF2
Tchem
Novelty: 0.00007856
p_int: 0.999999774
p_ni: 2.2e-7
p_wrong: 6e-9
Data Source: BioPlex
GMEB1
Tbio
Family: TF
Novelty: 0.10522678
p_int: 0.999987856
p_ni: 0.000012135
p_wrong: 8e-9
Data Source: BioPlex
GMEB2
Tdark
Family: TF
Novelty: 0.1945427
p_int: 0.999786861
p_ni: 0.000028288
p_wrong: 0.000184852
Data Source: BioPlex
AMPD2
Tchem
Family: Enzyme
Novelty: 0.01510718
p_int: 0.999681947
p_ni: 0.000318053
Data Source: BioPlex
PRDM10
Tbio
Family: TF; Epigenetic
Novelty: 0.03463517
p_int: 0.999387215
p_ni: 0.000612784
p_wrong: 1e-9
Data Source: BioPlex
C17orf80
Tbio
Novelty: 0.15267004
p_int: 0.998945255
p_ni: 0.001054745
Data Source: BioPlex
CCDC51
Tdark
Novelty: 1.19203634
p_int: 0.998396621
p_ni: 0.001016875
p_wrong: 0.000586504
Data Source: BioPlex
FAM171A2
Tdark
Novelty: 1.18763693
p_int: 0.992023672
p_ni: 0.007976322
p_wrong: 7e-9
Data Source: BioPlex
EXOC3
Tbio
Novelty: 0.01051955
p_int: 0.992016683
p_ni: 0.007983293
p_wrong: 2.3e-8
Data Source: BioPlex
VANGL1
Tbio
Novelty: 0.00968008
p_int: 0.985672711
p_ni: 0.014327289
Data Source: BioPlex
Publication Statistics
PubMed Score  778.44

PubMed score by year
PubTator Score  444.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: