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Tbio
CD36
Platelet glycoprotein 4

Protein Classes
Protein Summary
Description
Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, P ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309881
  • ENSP00000308165
  • ENSG00000135218
  • ENST00000394788
  • ENSP00000378268
  • ENST00000432207
  • ENSP00000411411
  • ENST00000433696
  • ENSP00000401863
  • ENST00000435819
  • ENSP00000399421
  • ENST00000447544
  • ENSP00000415743
  • ENST00000538969
  • ENSP00000439543
  • ENST00000544133
  • ENSP00000441956

Symbol
  • GP3B
  • GP4
  • FAT
  • GP4
  • GP3B
  • GPIV
  • CHDS7
  • PASIV
  • SCARB3
  • BDPLT10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
metabolite
1
gene perturbation
0.97
disease
0.79
molecular function
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 601.06   (req: < 5)
Gene RIFs: 337   (req: <= 3)
Antibodies: 1595   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 601.06   (req: >= 5)
Gene RIFs: 337   (req: > 3)
Antibodies: 1595   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 84
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
6
7
6
4.2
94.2
red blood cell distribution width
4
5
5
93.7
high density lipoprotein cholesterol measurement
3
3
3
90.5
mean platelet volume
3
1
3
80.6
mean reticulocyte volume
1
3
3
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
6
4.2
94.2
red blood cell distribution width
5
93.7
high density lipoprotein cholesterol measurement
3
90.5
mean platelet volume
3
80.6
mean reticulocyte volume
3
66.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD36 molecule
VGNC:13636
463949
Mouse
MGI:107899
12491
Rat
RGD:9322705
103690020
Dog
CD36 molecule
VGNC:38951
475931
Horse
CD36 molecule
VGNC:16261
100049847
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD36 molecule
Mouse
Rat
Dog
CD36 molecule
Horse
CD36 molecule
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16671-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (134)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cross-presentation of particulate exogenous antigens (phagosomes)
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Binding and Uptake of Ligands by Scavenger Receptors
Class I MHC mediated antigen processing & presentation
Cross-presentation of particulate exogenous antigens (phagosomes)
Gene Ontology Terms (100)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Protein-Protein Interactions (260)
1 – 10 of 260
CROT
Tbio
Family: Enzyme
Novelty: 0.01860427
p_int: 0.999585362
p_ni: 0.000001172
p_wrong: 0.000413466
Score: 0.269
Data Source: BioPlex,STRINGDB
TTMP
Tdark
Novelty: 0.22491726
p_int: 0.999049623
p_ni: 0.000942076
p_wrong: 0.000008301
Score: 0.29
Data Source: BioPlex,STRINGDB
MBOAT7
Tbio
Family: Enzyme
Novelty: 0.01861411
p_int: 0.935964478
p_ni: 0.064035522
Score: 0.199
Data Source: BioPlex,STRINGDB
FABP4
Tchem
Novelty: 0.00107707
Score: 0.964
Data Source: STRINGDB
DGAT1
Tclin
Family: Enzyme
Novelty: 0.00121009
Score: 0.963
Data Source: STRINGDB
FABP1
Tchem
Novelty: 0.00192691
Score: 0.958
Data Source: STRINGDB
PPARG
Tclin
Family: NR
Novelty: 0.00010033
Score: 0.954
Data Source: STRINGDB
SLC27A2
Tbio
Family: Transporter
Novelty: 0.01436035
Score: 0.954
Data Source: STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.951
Data Source: Reactome,STRINGDB
PPARA
Tclin
Family: NR
Novelty: 0.00017403
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  601.06

PubMed score by year
PubTator Score  1393.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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