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Tclin
FER
Tyrosine-protein kinase Fer

Protein Summary
Description
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-ne ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281092
  • ENSP00000281092
  • ENSG00000151422
  • ENST00000618353
  • ENSP00000484767

Symbol
  • TYK3
  • TYK3
  • PPP1R74
  • p94-Fer
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
interacting protein
0.91
drug perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.11   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 529   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.11   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 529   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
lorlatinib
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
1
2
66.9
intraocular pressure measurement
1
1
1
38.9
BMI-adjusted waist circumference
1
1
1
32.8
leukocyte count
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
66.9
intraocular pressure measurement
1
38.9
BMI-adjusted waist circumference
1
32.8
leukocyte count
1
13.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Receptor Tyrosine Kinases
Reactome
Signaling by SCF-KIT
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Receptor Tyrosine Kinases
Signaling by SCF-KIT
Gene Ontology Terms (51)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (44)
1 – 10 of 44
ARC
Tbio
Novelty: 0.00378953
p_int: 0.999999883
p_ni: 1.11e-7
p_wrong: 5e-9
Score: 0.689
Data Source: BioPlex,STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.999
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.999
Data Source: STRINGDB
CTNND1
Tbio
Novelty: 0.00335459
Score: 0.999
Data Source: STRINGDB
CTTN
Tbio
Novelty: 0.0017962
Score: 0.969
Data Source: STRINGDB
KITLG
Tbio
Novelty: 0.00036337
Score: 0.948
Data Source: Reactome,STRINGDB
JUP
Tbio
Novelty: 0.0081803
Score: 0.942
Data Source: STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.942
Data Source: STRINGDB
KIT
Tclin
Family: Kinase
Novelty: 0.00011237
Score: 0.923
Data Source: Reactome,STRINGDB
PTPN1
Tchem
Family: Enzyme
Novelty: 0.00065779
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.11

PubMed score by year
PubTator Score  61.85

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer