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Tchem
SELE
E-selectin

Protein Summary
Description
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333360
  • ENSP00000331736
  • ENSG00000007908

Symbol
  • ELAM1
  • ELAM
  • ESEL
  • CD62E
  • ELAM1
  • LECAM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
protein domain
0.97
chemical
0.92
disease
0.91
cell type or tissue
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3183.13   (req: < 5)
Gene RIFs: 317   (req: <= 3)
Antibodies: 1144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3183.13   (req: >= 5)
Gene RIFs: 317   (req: > 3)
Antibodies: 1144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 106
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
2
2
88.5
e-selectin measurement
1
1
1
82.2
monocyte count
1
1
1
78.3
myeloid white cell count
2
2
2
77.6
monocyte percentage of leukocytes
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
2
88.5
e-selectin measurement
1
82.2
monocyte count
1
78.3
myeloid white cell count
2
77.6
monocyte percentage of leukocytes
1
47.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
selectin E
VGNC:1537
736063
Macaque
selectin E
701538
Mouse
MGI:98278
20339
Rat
RGD:3654
25544
Dog
selectin E
VGNC:45980
403999
Species
Name
OMA
EggNOG
Inparanoid
Chimp
selectin E
Macaque
selectin E
Mouse
Rat
Dog
selectin E
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16581-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (247)
1 – 10 of 247
DIP2B
Tdark
Novelty:  0.14642544
p_int:  0.99922482
p_ni:  0.000751605
p_wrong:  0.000023574
Score:  0.313
Data Source:  BioPlex,STRINGDB
DIP2A
Tbio
Novelty:  0.09357918
p_int:  0.987563096
p_ni:  0.012436904
Score:  0.241
Data Source:  BioPlex,STRINGDB
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
p_int:  0.969552886
p_ni:  0.030447114
Score:  0.177
Data Source:  BioPlex,STRINGDB
MTMR1
Tbio
Family:  Enzyme
Novelty:  0.06694505
p_int:  0.854893334
p_ni:  0.145106645
p_wrong:  2e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
SBF1
Tbio
Novelty:  0.01814482
p_int:  0.799014943
p_ni:  0.200985035
p_wrong:  2.2e-8
Score:  0.207
Data Source:  BioPlex,STRINGDB
SELPLG
Tbio
Novelty:  0.0016359
Score:  0.994
Data Source:  Reactome,STRINGDB
CD44
Tbio
Novelty:  0.00011321
Score:  0.989
Data Source:  Reactome,STRINGDB
GLG1
Tbio
Novelty:  0.01332149
Score:  0.988
Data Source:  Reactome,STRINGDB
SPN
Tbio
Novelty:  0.00121061
Score:  0.968
Data Source:  Reactome,STRINGDB
ICAM1
Tchem
Novelty:  0.00009746
Score:  0.954
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3183.13

PubMed score by year
PubTator Score  2290.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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