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Tchem
PCSK2
Neuroendocrine convertase 2

Protein Summary
Description
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262545
  • ENSP00000262545
  • ENSG00000125851
  • ENST00000377899
  • ENSP00000367131
  • ENST00000536609
  • ENSP00000437458

Symbol
  • NEC2
  • PC2
  • NEC2
  • SPC2
  • NEC 2
  • NEC-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.86
PubMedID
0.76
cellular component
0.75
phenotype
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.56   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.56   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1
1
1
85.4
wellbeing measurement
2
1
2
56.5
self reported educational attainment
1
1
1
54.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
85.4
wellbeing measurement
2
56.5
self reported educational attainment
1
54.7
Pathways (5)
Insulin processing (R-HSA-264876)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin processing
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Insulin processing
Metabolism of proteins
Peptide hormone metabolism
Protein-Protein Interactions (77)
1 – 10 of 77
SCG5
Tbio
Novelty: 0.00379377
Score: 0.994
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.955
Data Source: Reactome,STRINGDB
CPE
Tbio
Family: Enzyme
Novelty: 0.00197792
Score: 0.917
Data Source: STRINGDB
SYT4
Tbio
Novelty: 0.01527865
Score: 0.865
Data Source: STRINGDB
SYT11
Tbio
Novelty: 0.02472551
Score: 0.783
Data Source: STRINGDB
THBD
Tbio
Novelty: 0.00039359
Score: 0.753
Data Source: STRINGDB
CPZ
Tbio
Family: Enzyme
Novelty: 0.00100967
Score: 0.71
Data Source: STRINGDB
CPN1
Tchem
Family: Enzyme
Novelty: 0.00331889
Score: 0.71
Data Source: STRINGDB
IAPP
Tbio
Novelty: 0.0005195
Score: 0.689
Data Source: STRINGDB
CHGA
Tbio
Novelty: 0.00033267
Score: 0.662
Data Source: STRINGDB
Publication Statistics
PubMed Score  169.56

PubMed score by year
PubTator Score  135.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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