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Tclin
PDE6A
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Protein Summary
Description
This protein participates in processes of transmission and amplification of the visual signal. This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255266
  • ENSP00000255266
  • ENSG00000132915

Symbol
  • PDEA
  • PDEA
  • RP43
  • CGPR-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
gene perturbation
0.87
protein domain
0.85
biological process
0.71
tissue sample
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.21   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.21   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 46
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dipyridamole
Rendered image for dipyridamole
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
freckles
1
1
0
1.4
74.2
1
1
0
1.1
67.7
monocyte percentage of leukocytes
1
1
1
65.5
solar lentigines measurement
1
1
0
1.3
52.4
mean reticulocyte volume
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
freckles
0
1.4
74.2
0
1.1
67.7
monocyte percentage of leukocytes
1
65.5
solar lentigines measurement
0
1.3
52.4
mean reticulocyte volume
1
49.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 6A
VGNC:4124
462184
Macaque
phosphodiesterase 6A
677688
Mouse
MGI:97524
225600
Rat
RGD:1306835
307401
Dog
phosphodiesterase 6A
VGNC:44357
403620
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 6A
Macaque
phosphodiesterase 6A
Mouse
Rat
Dog
phosphodiesterase 6A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P16499-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Activation of the phototransduction cascade (R-HSA-2485179)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the phototransduction cascade
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Activation of the phototransduction cascade
Beta-catenin independent WNT signaling
Ca2+ pathway
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (157)
1 – 10 of 157
PDE6G
Tclin
Family:  Enzyme
Novelty:  0.03113994
Score:  0.996
Data Source:  Reactome,STRINGDB
CNGB1
Tbio
Family:  IC
Novelty:  0.01034916
Score:  0.993
Data Source:  STRINGDB
PDE6H
Tclin
Family:  Enzyme
Novelty:  0.0524804
Score:  0.984
Data Source:  STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
Score:  0.98
Data Source:  STRINGDB
CNGA1
Tchem
Family:  IC
Novelty:  0.00848214
Score:  0.979
Data Source:  STRINGDB
GNGT2
Tbio
Novelty:  0.0468008
Score:  0.972
Data Source:  STRINGDB
GNAT1
Tbio
Novelty:  0.03042002
Score:  0.968
Data Source:  Reactome,STRINGDB
GNAT2
Tbio
Novelty:  0.01683655
Score:  0.958
Data Source:  Reactome,STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.957
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.95
Data Source:  STRINGDB
Publication Statistics
PubMed Score  41.21

PubMed score by year
PubTator Score  86.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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