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Tclin
TSHR
Thyrotropin receptor

Protein Summary
Description
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity). The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342443
  • ENSP00000340113
  • ENSG00000165409
  • ENST00000554435
  • ENSP00000450549

Symbol
  • LGR3
  • LGR3
  • CHNG1
  • hTSHR-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
protein domain
0.85
disease
0.8
disease perturbation
0.79
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1625.39   (req: < 5)
Gene RIFs: 234   (req: <= 3)
Antibodies: 1081   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1625.39   (req: >= 5)
Gene RIFs: 234   (req: > 3)
Antibodies: 1081   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (221)
LAMA3
Tbio
Novelty:  0.00733792
p_int:  0.987295952
p_ni:  0.012676485
p_wrong:  0.000027563
Score:  0.247
Data Source:  BioPlex,STRINGDB
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.956270812
p_ni:  0.043729188
Score:  0.178
Data Source:  BioPlex,STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
p_int:  0.951607631
p_ni:  0.003046031
p_wrong:  0.045346338
Score:  0.19
Data Source:  BioPlex,STRINGDB
MOCOS
Tbio
Family:  Enzyme
Novelty:  0.05022905
p_int:  0.946301273
p_ni:  0.053695012
p_wrong:  0.000003715
Score:  0.173
Data Source:  BioPlex,STRINGDB
BORA
Tbio
Novelty:  0.0374925
p_int:  0.909799974
p_ni:  0.090061699
p_wrong:  0.000138328
Score:  0.189
Data Source:  BioPlex,STRINGDB
PC
Tbio
Family:  Enzyme
Novelty:  0.00271694
p_int:  0.878394362
p_ni:  0.121605638
Score:  0.525
Data Source:  BioPlex,STRINGDB
MLF1
Tbio
Novelty:  0.0239522
p_int:  0.788598376
p_ni:  0.211401624
Data Source:  BioPlex
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.769791223
p_ni:  0.230208777
Data Source:  BioPlex
TSHB
Tbio
Novelty:  0.00194403
Score:  0.983
Data Source:  Reactome,STRINGDB
P84996
Tbio
Novelty:  0.00284739
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Hormone ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Hormone ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.4
96.8
neutrophil count
3
3
3
71.7
high density lipoprotein cholesterol measurement
3
3
3
61.2
myeloid white cell count
1
1
1
60
albuminuria
1
1
0
30.7
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
96.8
neutrophil count
3
71.7
high density lipoprotein cholesterol measurement
3
61.2
myeloid white cell count
1
60
albuminuria
0
30.7
58.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyroid stimulating hormone receptor
VGNC:3294
453077
Macaque
thyroid stimulating hormone receptor
574251
Mouse
MGI:98849
22095
Rat
RGD:3911
25360
Dog
thyroid stimulating hormone receptor
VGNC:47902
403968
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyroid stimulating hormone receptor
Macaque
thyroid stimulating hormone receptor
Mouse
Rat
Dog
thyroid stimulating hormone receptor
Publication Statistics
PubMed Score 1625.39
PubMed score by year
PubTator Score 2607.72
PubTator score by year
Patents
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Related Publications
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PMID
Year
Title